| Literature DB >> 19115126 |
Negar Khanlou1, David J Moore, Gursharan Chana, Mariana Cherner, Deborah Lazzaretto, Sharron Dawes, Igor Grant, Eliezer Masliah, Ian P Everall.
Abstract
The frequency of neurodegenerative markers among long surviving human immunodeficiency virus (HIV)-infected individuals is unknown, therefore, the present study investigated the frequency of alpha-synuclein, beta-amyloid, and HIV-associated brain pathology in the brains of older HIV-infected individuals. We examined the substantia nigra of 73 clinically well-characterized HIV-infected individuals aged 50 to 76 years from the National NeuroAIDS Tissue Consortium. We also examined the frontal and temporal cortical regions of a subset of 36 individuals. Neuritic alpha-synuclein expression was found in 16% (12/73) of the substantia nigra of the HIV+cases and none of the older control cases (0/18). beta-Amyloid deposits were prevalent and found in nearly all of the HIV+cases (35/36). Despite these increases of degenerative pathology, HIV-associated brain pathology was present in only 10% of cases. Among older HIV+adults, HIV-associated brain pathology does not appear elevated; however, the frequency of both alpha-synuclein and beta-amyloid is higher than that found in older healthy persons. The increased prevalence of alpha-synuclein and beta-amyloid in the brains of older HIV-infected individuals may predict an increased risk of developing neurodegenerative disease.Entities:
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Year: 2009 PMID： 19115126 PMCID： PMC3979854 DOI： 10.1080/13550280802578075
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643