Literature DB >> 11703371

Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-gamma in their lungs.

I V Lyadova1, H M Vordermeier, E B Eruslanov, S V Khaidukov, A S Apt, R G Hewinson.   

Abstract

Local immune reactivity in the lungs of BALB/c mice was studied following (i) intranasal (i.n.) vaccination with Mycobacterium bovis BCG, (ii) intravenous (i.v.) challenge with a virulent M. bovis field isolate and (iii) i.n. vaccination with M. bovis BCG followed by i.v. challenge with an M. bovis field isolate. The results demonstrated that i.n. vaccination with BCG induced a high degree of protection against systemic M. bovis challenge, and that this protection correlated with a rapid production of IFN-gamma after M. bovis challenge by lung T cells from vaccinated mice.

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Year:  2001        PMID： 11703371      PMCID： PMC1906185          DOI： 10.1046/j.1365-2249.2001.01667.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  26 in total

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5.  Pulmonary immune responses during primary mycobacterium bovis- Calmette-Guerin bacillus infection in C57Bl/6 mice.

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2.  CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotype.

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3.  Investigations of TB vaccine-induced mucosal protection in mice.

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5.  Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis.

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6.  Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosis.

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9.  Intranasal bacille Calmette-Guerin (BCG) vaccine dosage needs balancing between protection and lung pathology.

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10.  Lung cell responses to M. tuberculosis in genetically susceptible and resistant mice following intratracheal challenge.

Authors:  E B Eruslanov; K B Majorov; M O Orlova; V V Mischenko; T K Kondratieva; A S Apt; I V Lyadova
Journal:  Clin Exp Immunol       Date:  2004-01       Impact factor: 4.330
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