OBJECTIVE: To examine the efficacy of intravenous porcine secretin for the treatment of autistic disorder. METHOD: Randomized, double-blind, placebo-controlled, crossover design. Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4. Subjects were given the Autism Diagnostic Observation Schedule (ADOS) and other pertinent developmental measures at baseline and at weeks 4 and 8 to assess drug effects. RESULTS: For the primary efficacy analysis, change of ADOS social-communication total score from week 0 to week 4, no statistically significant difference was obtained between placebo (-0.8 +/- 2.9) and secretin groups (-0.6 +/- 1.4; t54 = 0.346, p < .73). The other measures showed no treatment effect for secretin compared with placebo. CONCLUSION: There was no evidence for efficacy of secretin in this randomized, placebo-controlled, double-blind trial.
RCT Entities:
OBJECTIVE: To examine the efficacy of intravenous porcine secretin for the treatment of autistic disorder. METHOD: Randomized, double-blind, placebo-controlled, crossover design. Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4. Subjects were given the Autism Diagnostic Observation Schedule (ADOS) and other pertinent developmental measures at baseline and at weeks 4 and 8 to assess drug effects. RESULTS: For the primary efficacy analysis, change of ADOS social-communication total score from week 0 to week 4, no statistically significant difference was obtained between placebo (-0.8 +/- 2.9) and secretin groups (-0.6 +/- 1.4; t54 = 0.346, p < .73). The other measures showed no treatment effect for secretin compared with placebo. CONCLUSION: There was no evidence for efficacy of secretin in this randomized, placebo-controlled, double-blind trial.
Authors: Lauren S Wakschlag; Bennett L Leventhal; Margaret J Briggs-Gowan; Barbara Danis; Kate Keenan; Carri Hill; Helen L Egger; Domenic Cicchetti; Alice S Carter Journal: Clin Child Fam Psychol Rev Date: 2005-09
Authors: Daniel Braunschweig; Paul Ashwood; Paula Krakowiak; Irva Hertz-Picciotto; Robin Hansen; Lisa A Croen; Isaac N Pessah; Judy Van de Water Journal: Neurotoxicology Date: 2007-11-06 Impact factor: 4.294
Authors: Rebecca Grzadzinski; Themba Carr; Costanza Colombi; Kelly McGuire; Sarah Dufek; Andrew Pickles; Catherine Lord Journal: J Autism Dev Disord Date: 2016-07
Authors: Mikle South; Brenda J Williams; William M McMahon; Thomas Owley; Pauline A Filipek; E Shernoff; Christine Corsello; Janet E Lainhart; Rebecca Landa; Sally Ozonoff Journal: J Autism Dev Disord Date: 2002-12
Authors: Catherine Lord; Ann Wagner; Sally Rogers; Peter Szatmari; Michael Aman; Tony Charman; Geraldine Dawson; V Mark Durand; Lee Grossman; Donald Guthrie; Sandra Harris; Connie Kasari; Lee Marcus; Susan Murphy; Samuel Odom; Andrew Pickles; Lawrence Scahill; Evelyn Shaw; Bryna Siegel; Marian Sigman; Wendy Stone; Tristram Smith; Paul Yoder Journal: J Autism Dev Disord Date: 2005-12