A Tavani1, C Pelucchi, E Negri, M Bertuzzi, C La Vecchia. 1. Istituto di Ricerche Farmacologiche "Mario Negri", Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy. tavani@marionegri.it
Abstract
BACKGROUND: The relation between n-3 polyunsaturated fatty acids (PUFAs), fish intake, and risk of coronary heart disease is controversial. METHODS AND RESULTS: An Italian case-control study including 507 patients with nonfatal acute myocardial infarction (AMI) and 478 hospital controls found a multivariate odds ratio (OR) of 0.67 (95% CI, 0.47 to 0.95) for the highest n-3 PUFA intake and 0.68 (95% CI, 0.47 to 0.98) for an intake of >1 portion of fish per week compared with >/=2 portions per week. CONCLUSIONS: Small amounts of n-3 PUFAs may be inversely related to AMI risk in this low-risk population.
BACKGROUND: The relation between n-3 polyunsaturated fatty acids (PUFAs), fish intake, and risk of coronary heart disease is controversial. METHODS AND RESULTS: An Italian case-control study including 507 patients with nonfatal acute myocardial infarction (AMI) and 478 hospital controls found a multivariate odds ratio (OR) of 0.67 (95% CI, 0.47 to 0.95) for the highest n-3 PUFA intake and 0.68 (95% CI, 0.47 to 0.98) for an intake of >1 portion of fish per week compared with >/=2 portions per week. CONCLUSIONS: Small amounts of n-3 PUFAs may be inversely related to AMI risk in this low-risk population.
Authors: Hernan A Bazan; Yan Lu; Deepu Thoppil; Tamara N Fitzgerald; Song Hong; Alan Dardik Journal: Vascul Pharmacol Date: 2009-09-04 Impact factor: 5.773