Literature DB >> 11694883

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.

R K Leung1, K Thomson, A Gallimore, E Jones, M Van den Broek, S Sierro, A R Alsheikhly, A McMichael, A Rahemtulla.   

Abstract

The mechanism of T cell lineage commitment remains controversial; to examine it we deleted the CD4-silencer element in the germ line of a mouse using a combination of gene targeting and Cre/LoxP-mediated recombination. We found that these mice were unable to extinguish CD4 expression either in immature thymocytes or mature CD8+ cytotoxic T cells (CTLs), which resulted in the development of major histocompatibility complex class II-restricted double-positive CTLs in the periphery. This finding strongly supports a stochastic over an instructive mechanism of coreceptor down-regulation.

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Year:  2001        PMID： 11694883     DOI： 10.1038/ni733

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  21 in total

Review 1.  Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

Authors:  Alfred Singer; Stanley Adoro; Jung-Hyun Park
Journal:  Nat Rev Immunol       Date:  2008-10       Impact factor: 53.106

2.  Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.

Authors:  Andrea C Carpenter; Elizabeth Wohlfert; Laura B Chopp; Melanie S Vacchio; Jia Nie; Yongmei Zhao; Jyoti Shetty; Qi Xiao; Callie Deng; Bao Tran; Margaret Cam; Matthias M Gaida; Yasmine Belkaid; Rémy Bosselut
Journal:  J Immunol       Date:  2017-07-28       Impact factor: 5.422

3.  The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.

Authors:  Shinya Sakaguchi; Matthias Hombauer; Ivan Bilic; Yoshinori Naoe; Alexandra Schebesta; Ichiro Taniuchi; Wilfried Ellmeier
Journal:  Nat Immunol       Date:  2010-04-11       Impact factor: 25.606

Review 4.  Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.

Authors:  Lie Wang; Yumei Xiong; Rémy Bosselut
Journal:  Semin Immunol       Date:  2011-10-01       Impact factor: 11.130

5.  Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3.

Authors:  Merav Yarmus; Eilon Woolf; Yael Bernstein; Ofer Fainaru; Varda Negreanu; Ditsa Levanon; Yoram Groner
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-01       Impact factor: 11.205

6.  Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.

Authors:  Stanley Adoro; Batu Erman; Sophia D Sarafova; François Van Laethem; Jung-Hyun Park; Lionel Feigenbaum; Alfred Singer
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

7.  A silencer-proximal intronic region is required for sustained CD4 expression in postselection thymocytes.

Authors:  David M Henson; Chun Chou; Nagisa Sakurai; Takeshi Egawa
Journal:  J Immunol       Date:  2014-04-11       Impact factor: 5.422

Review 8.  What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.

Authors:  Melanie S Vacchio; Rémy Bosselut
Journal:  J Immunol       Date:  2016-06-15       Impact factor: 5.422

9.  Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

Authors:  Sophia D Sarafova; Francois Van Laethem; Stanley Adoro; Terry Guinter; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Journal:  Immunity       Date:  2009-09-10       Impact factor: 31.745

Review 10.  RUNX proteins in transcription factor networks that regulate T-cell lineage choice.

Authors:  Amélie Collins; Dan R Littman; Ichiro Taniuchi
Journal:  Nat Rev Immunol       Date:  2009-02       Impact factor: 53.106
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