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Literature DB >> 21963088

Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.

Abstract

The divergence of the two αβ T cell subsets defined by the mutually exclusive expression of CD4 and CD8 glycoproteins is an important event during the intrathymic differentiation of T lymphocytes. This reviews briefly summarizes the mechanisms that promote commitment to the CD4 or CD8 lineage in the thymus, and discusses the transcription factor circuits and epigenetic mechanisms that concur to maintain lineage integrity in post-thymic cells and yet allow effector cell differentiation. Published by Elsevier Ltd.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2011 PMID： 21963088 PMCID： PMC3740965 DOI： 10.1016/j.smim.2011.08.008

Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130

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