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Literature DB >> 11691838

A zebrafish nanos-related gene is essential for the development of primordial germ cells.

M Köprunner¹, C Thisse, B Thisse, E Raz.

Abstract

Asymmetrically distributed cytoplasmic determinants collectively termed germ plasm have been shown to play an essential role in the development of primordial germ cells (PGCs). Here, we report the identification of a nanos-like (nanos1) gene, which is expressed in the germ plasm and in the PGCs of the zebrafish. We find that several mechanisms act in concert to restrict the activity of Nanos1 to the germ cells including RNA localization and control over the stability and translatability of the RNA. Reducing the level of Nanos1 in zebrafish embryos revealed an essential role for the protein in ensuring proper migration and survival of PGCs in this vertebrate model organism.

Entities: Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11691838 PMCID： PMC312811 DOI： 10.1101/gad.212401

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

40 in total

1. Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.

Authors: C G Eberhart; J Z Maines; S A Wasserman
Journal: Nature Date: 1996-06-27 Impact factor: 49.962

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Authors: E R Gavis; R Lehmann
Journal: Nature Date: 1994-05-26 Impact factor: 49.962

3. The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo.

Authors: P P Tam; S X Zhou
Journal: Dev Biol Date: 1996-08-25 Impact factor: 3.582

4. Mutations that suppress the thermosensitivity of green fluorescent protein.

Authors: K R Siemering; R Golbik; R Sever; J Haseloff
Journal: Curr Biol Date: 1996-12-01 Impact factor: 10.834

5. A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.

Authors: B Hay; L Y Jan; Y N Jan
Journal: Cell Date: 1988-11-18 Impact factor: 41.582

6. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.

Authors: P Lemaire; N Garrett; J B Gurdon
Journal: Cell Date: 1995-04-07 Impact factor: 41.582

7. Essential role of the posterior morphogen nanos for germline development in Drosophila.

Authors: S Kobayashi; M Yamada; M Asaoka; T Kitamura
Journal: Nature Date: 1996-04-25 Impact factor: 49.962

8. Stages of embryonic development of the zebrafish.

Authors: C B Kimmel; W W Ballard; S R Kimmel; B Ullmann; T F Schilling
Journal: Dev Dyn Date: 1995-07 Impact factor: 3.780

9. Nanos is the localized posterior determinant in Drosophila.

Authors: C Wang; R Lehmann
Journal: Cell Date: 1991-08-23 Impact factor: 41.582

10. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

Authors: R Reijo; T Y Lee; P Salo; R Alagappan; L G Brown; M Rosenberg; S Rozen; T Jaffe; D Straus; O Hovatta
Journal: Nat Genet Date: 1995-08 Impact factor: 38.330

153 in total

1. Effects of transgenic sterilization constructs and their repressor compounds on hatch, developmental rate and early survival of electroporated channel catfish embryos and fry.

Authors: Baofeng Su; Mei Shang; Chao Li; Dayan A Perera; Carl A Pinkert; Michael H Irwin; Eric Peatman; Peter Grewe; Jawahar G Patil; Rex A Dunham
Journal: Transgenic Res Date: 2014-11-04 Impact factor: 2.788

A zebrafish nanos-related gene is essential for the development of primordial germ cells.

1. Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia.

2. Translational regulation of nanos by RNA localization.

3. The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo.

4. Mutations that suppress the thermosensitivity of green fluorescent protein.

5. A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.

6. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.

7. Essential role of the posterior morphogen nanos for germline development in Drosophila.

8. Stages of embryonic development of the zebrafish.

9. Nanos is the localized posterior determinant in Drosophila.

10. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

1. Effects of transgenic sterilization constructs and their repressor compounds on hatch, developmental rate and early survival of electroporated channel catfish embryos and fry.

2. Production of maternal-zygotic mutant zebrafish by germ-line replacement.

3. Nanos suppresses somatic cell fate in Drosophila germ line.

4. Imaging protein activity in live embryos using fluorescence resonance energy transfer biosensors.

5. Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells.

6. A functional genomic screen in planarians identifies novel regulators of germ cell development.

7. Repression of zygotic gene expression in the Xenopus germline.

8. A conserved germline multipotency program.

9. Optimization of mRNA design for protein expression in the crustacean Daphnia magna.

Review 10. Nanos genes and their role in development and beyond.