Literature DB >> 11689679

Vaccination with attenuated simian immunodeficiency virus by DNA inoculation.

S J Kent1, C J Dale, S Preiss, J Mills, D Campagna, D F Purcell.   

Abstract

Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIV(mac239)) DNA or SIV(mac239) DNA containing a single deletion in the 3' nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIV(mac239) DNA containing identical deletions in both the 5' LTR and 3' nef/LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIV(mac251) challenge.

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Year:  2001        PMID： 11689679      PMCID： PMC114784          DOI： 10.1128/JVI.75.23.11930-11934.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies.

Authors:  G Marzio; K Verhoef; M Vink; B Berkhout
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  Risks of handling HIV.

Authors:  N L Letvin; C I Lord; N W King; M S Wyand; K V Myrick; W A Haseltine
Journal:  Nature       Date:  1991-02-14       Impact factor: 49.962

3.  Importance of the nef gene for maintenance of high virus loads and for development of AIDS.

Authors:  H W Kestler; D J Ringler; K Mori; D L Panicali; P K Sehgal; M D Daniel; R C Desrosiers
Journal:  Cell       Date:  1991-05-17       Impact factor: 41.582

4.  Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.

Authors:  S J Kent; S L Hu; L Corey; W R Morton; P D Greenberg
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

5.  Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma.

Authors:  C J Dale; A Zhao; S L Jones; D B Boyle; I A Ramshaw; S J Kent
Journal:  J Med Primatol       Date:  2000-08       Impact factor: 0.667

6.  Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques.

Authors:  T W Baba; Y S Jeong; D Pennick; R Bronson; M F Greene; R M Ruprecht
Journal:  Science       Date:  1995-03-24       Impact factor: 47.728

7.  Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene.

Authors:  M D Daniel; F Kirchhoff; S C Czajak; P K Sehgal; R C Desrosiers
Journal:  Science       Date:  1992-12-18       Impact factor: 47.728

8.  Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.

Authors:  D F Purcell; M A Martin
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

9.  Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genes.

Authors:  J S Gibbs; D A Regier; R C Desrosiers
Journal:  AIDS Res Hum Retroviruses       Date:  1994-04       Impact factor: 2.205

10.  Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients.

Authors:  N J Deacon; A Tsykin; A Solomon; K Smith; M Ludford-Menting; D J Hooker; D A McPhee; A L Greenway; A Ellett; C Chatfield; V A Lawson; S Crowe; A Maerz; S Sonza; J Learmont; J S Sullivan; A Cunningham; D Dwyer; D Dowton; J Mills
Journal:  Science       Date:  1995-11-10       Impact factor: 47.728
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  11 in total

1.  Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes.

Authors:  Miranda Z Smith; C Jane Dale; Robert De Rose; Ivan Stratov; Caroline S Fernandez; Andrew G Brooks; Jason Weinfurter; Kendall Krebs; Cara Riek; David I Watkins; David H O'connor; Stephen J Kent
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

2.  Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques.

Authors:  Caroline S Fernandez; Jeanette C Reece; Uus Saepuloh; Robert De Rose; Diah Ishkandriati; David H O'Connor; Roger W Wiseman; Stephen J Kent
Journal:  Immunogenetics       Date:  2011-05-10       Impact factor: 2.846

3.  MHC class I allele frequencies in pigtail macaques of diverse origin.

Authors:  Bridget F Pratt; David H O'Connor; Bernard A P Lafont; Joseph L Mankowski; Caroline S Fernandez; Retno Triastuti; Andrew G Brooks; Stephen J Kent; Miranda Z Smith
Journal:  Immunogenetics       Date:  2006-11-10       Impact factor: 2.846

4.  Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis.

Authors:  Wendy R Winnall; Sarah B Lloyd; Robert De Rose; Sheilajen Alcantara; Thakshila H Amarasena; Mark P Hedger; Jane E Girling; Stephen J Kent
Journal:  J Leukoc Biol       Date:  2015-01-20       Impact factor: 4.962

5.  AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine.

Authors:  Mauro Pistello; Donatella Matteucci; Francesca Bonci; Patrizia Isola; Paola Mazzetti; Lucia Zaccaro; Antonio Merico; Daniela Del Mauro; Norman Flynn; Mauro Bendinelli
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

6.  Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence.

Authors:  Andreas Jekle; Birgit Schramm; Prerana Jayakumar; Verena Trautner; Dominique Schols; Erik De Clercq; John Mills; Suzanne M Crowe; Mark A Goldsmith
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

7.  Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge.

Authors:  Miranda Z Smith; Tedi E Asher; Vanessa Venturi; Miles P Davenport; Daniel C Douek; David A Price; Stephen J Kent
Journal:  J Virol       Date:  2008-05-28       Impact factor: 5.103

8.  Decreased neurotropism of nef long terminal repeat (nef/LTR)-deleted simian immunodeficiency virus.

Authors:  Katherine A Thompson; Stephen J Kent; Michelle E Gahan; Damian F J Purcell; Catriona A McLean; Scott Preiss; C Jane Dale; Steven L Wesselingh
Journal:  J Neurovirol       Date:  2003-08       Impact factor: 2.643

9.  Novel Strategy To Adapt Simian-Human Immunodeficiency Virus E1 Carrying env from an RV144 Volunteer to Rhesus Macaques: Coreceptor Switch and Final Recovery of a Pathogenic Virus with Exclusive R5 Tropism.

Authors:  Hanna B Scinto; Sandeep Gupta; Swati Thorat; Muhammad M Mukhtar; Anthony Griffiths; Jennifer Delgado; Elizabeth Plake; Hemant K Vyas; Amanda Strickland; Siddappa N Byrareddy; David C Montefiori; Celia LaBranche; Ranajit Pal; Jim Treece; Sharon Orndorff; Maria Grazia Ferrari; Deborah Weiss; Agnes-Laurence Chenine; Robert McLinden; Nelson Michael; Jerome H Kim; Merlin L Robb; Supachai Rerks-Ngarm; Punnee Pitisuttithum; Sorachai Nitayaphan; Ruth M Ruprecht
Journal:  J Virol       Date:  2018-06-29       Impact factor: 5.103

10.  Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.

Authors:  Liyen Loh; Jeanette C Reece; Caroline S Fernandez; Sheilajen Alcantara; Robert Center; Jane Howard; Damian F J Purcell; Mehala Balamurali; Janka Petravic; Miles P Davenport; Stephen J Kent
Journal:  PLoS Pathog       Date:  2009-04-10       Impact factor: 6.823
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