| Literature DB >> 11687976 |
S C Wang1, K Makino, W Xia, J S Kim, S A Im, H Peng, S C Mok, S E Singletary, M C Hung.
Abstract
DOC-2/hDab-2 was identified due to the loss of its expression in primary ovarian cancer cells. It is believed that loss of DOC-2/hDab-2 expression is one of the early events of ovarian malignancy. These results suggest a function of DOC-2/hDab-2 as a tumor suppressor. However, it is not clear how DOC-2/hDab-2 negatively regulates cancer cell growth. In this report, we demonstrate that DOC-2/hDab-2 expression in breast cancer cells resulted in sensitivity to suspension-induced cell death (anoikis). This event was associated with the down-regulation of the integrin-linked kinase (ILK) activity. Since ILK is a key factor in regulating the cellular signaling in responding to the extracellular signals through adhesion molecules like integrins, our results indicate that DOC-2/hDab-2 may prevent tumor growth and invasion by modulating the anti-apoptotic ILK pathway.Entities:
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Year: 2001 PMID： 11687976 DOI： 10.1038/sj.onc.1204873
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867