Literature DB >> 20708583

Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.

Simon W Moore1, Pere Roca-Cusachs, Michael P Sheetz.   

Abstract

Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20708583      PMCID: PMC5319208          DOI: 10.1016/j.devcel.2010.07.018

Source DB:  PubMed          Journal:  Dev Cell        ISSN: 1534-5807            Impact factor:   12.270


  181 in total

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Review 7.  Integrins and the actin cytoskeleton.

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  180 in total

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7.  Cells test substrate rigidity by local contractions on submicrometer pillars.

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Review 8.  Role of the extracellular matrix in epithelial morphogenesis: a view from C. elegans.

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