J Kotzan1, W Wade, H H Yu. 1. College of Pharmacy, University of Georgia, Athens 30602, USA. jkotzan@rx.uga.edu
Abstract
PURPOSE: The purpose of the study was to determine the incidence of GERD associated with prescription NSAID consumption. METHODS: All Georgia Medicaid patients > 25 years of age and continuously eligible for 1996, 1997, and 1998 were included in the study. Patients were excluded if they received a GERD diagnoses during 1996 and 1997. Patients were observed in 1998 and classified into GERD and control cohorts. Comorbidities, demographics, and NSAID prescription consumption were retained and modeled with logistic regression. RESULTS: The absolute risk of developing GERD without previous NSAID consumption was 0.38. The absolute risk of developing GERD for those patients who consumed one or more NSAID prescriptions during 1996 and 1997 was 0.80. Thus, the relative risk of GERD for NSAID patients was 2.11. GERD was significantly associated with one or more NSAID prescriptions (OR = 1.82), age (OR = 1.05 for 5 year range), gender (OR = 1.31 for females), asthma (OR = 3.24), obesity (OR = 2.77), hiatal hernia (OR = 4.17), tobacco use (OR = 2.56), and alcohol (OR = 1.83). The initial NSAID prescription was responsible for the greatest marginal increase in GERD. CONCLUSIONS: Our study suggests that NSAIDs are associated with GERD especially for females, alcohol and tobacco users, and patients with asthma, hiatal hernia, or obesity.
PURPOSE: The purpose of the study was to determine the incidence of GERD associated with prescription NSAID consumption. METHODS: All Georgia Medicaid patients > 25 years of age and continuously eligible for 1996, 1997, and 1998 were included in the study. Patients were excluded if they received a GERD diagnoses during 1996 and 1997. Patients were observed in 1998 and classified into GERD and control cohorts. Comorbidities, demographics, and NSAID prescription consumption were retained and modeled with logistic regression. RESULTS: The absolute risk of developing GERD without previous NSAID consumption was 0.38. The absolute risk of developing GERD for those patients who consumed one or more NSAID prescriptions during 1996 and 1997 was 0.80. Thus, the relative risk of GERD for NSAID patients was 2.11. GERD was significantly associated with one or more NSAID prescriptions (OR = 1.82), age (OR = 1.05 for 5 year range), gender (OR = 1.31 for females), asthma (OR = 3.24), obesity (OR = 2.77), hiatal hernia (OR = 4.17), tobacco use (OR = 2.56), and alcohol (OR = 1.83). The initial NSAID prescription was responsible for the greatest marginal increase in GERD. CONCLUSIONS: Our study suggests that NSAIDs are associated with GERD especially for females, alcohol and tobacco users, and patients with asthma, hiatal hernia, or obesity.
Authors: M B Fennerty; D Castell; A M Fendrick; M Halpern; D Johnson; P J Kahrilas; D Leiberman; J E Richter; R E Sampliner Journal: Arch Intern Med Date: 1996-03-11
Authors: M Fein; M P Ritter; T R DeMeester; S Oberg; J H Peters; J A Hagen; C G Bremner Journal: J Gastrointest Surg Date: 1999 Jul-Aug Impact factor: 3.452
Authors: L M Brown; C A Swanson; G Gridley; G M Swanson; J B Schoenberg; R S Greenberg; D T Silverman; L M Pottern; R B Hayes; A G Schwartz Journal: J Natl Cancer Inst Date: 1995-01-18 Impact factor: 13.506
Authors: Núria Piqué; Marta Ponce; Vicente Garrigues; Luis Rodrigo; Félix Calvo; Carlos Martín de Argila; Fernando Borda; Antonio Naranjo; Javier Alcedo; María José Soria; Enrique Rey; Luis Bujanda; Javier P Gisbert; David Suarez; Xavier Calvet; Julio Ponce Journal: United European Gastroenterol J Date: 2015-07-24 Impact factor: 4.623
Authors: Jonas F Ludvigsson; Pertti Aro; Marjorie M Walker; Michael Vieth; Lars Agréus; Nicholas J Talley; Joseph A Murray; Jukka Ronkainen Journal: Scand J Gastroenterol Date: 2013-05-14 Impact factor: 2.423
Authors: Maria Pina Dore; Emmanouil Maragkoudakis; Ken Fraley; Antonietta Pedroni; Vincenza Tadeu; Giuseppe Realdi; David Y Graham; Giuseppe Delitala; Hoda M Malaty Journal: Dig Dis Sci Date: 2007-11-22 Impact factor: 3.199
Authors: Johannes Lenglinger; Stephanie Fischer See; Lukas Beller; Enrico P Cosentini; Reza Asari; Fritz Wrba; Martin Riegler; Sebastian F Schoppmann Journal: Wien Klin Wochenschr Date: 2013-09-06 Impact factor: 1.704