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Literature DB >> 11682268

A brief history of hypocretin/orexin and narcolepsy.

J M Siegel¹, R Moore, T Thannickal, R Nienhuis.

Abstract

The hypothalamic peptides named the orexins, or hypocretins, were discovered in 1998. In 1999 it was established that genetic narcolepsy could be caused by mutations in the genes synthesizing these peptides or their receptors. In September of 2000 it was found that most human narcolepsy is caused by loss of hypocretin cells, most likely as a result of a degenerative process. This paper reviews these events and their implications for our understanding of brain arousal and motor control systems.

Entities: Chemical

Mesh：

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Year: 2001 PMID： 11682268 PMCID： PMC8788648 DOI： 10.1016/S0893-133X(01)00317-7

Source DB: PubMed Journal: Neuropsychopharmacology ISSN： 0893-133X Impact factor: 7.853

44 in total

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Authors: G Aston-Jones; F E Bloom
Journal: J Neurosci Date: 1981-08 Impact factor: 6.167

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Journal: J Pharmacol Exp Ther Date: 1999-04 Impact factor: 4.030

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Journal: Cell Date: 1998-02-20 Impact factor: 41.582

8. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

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Journal: Cell Date: 1999-08-20 Impact factor: 41.582

9. Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla.

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10. Reduced number of hypocretin neurons in human narcolepsy.

Authors: T C Thannickal; R Y Moore; R Nienhuis; L Ramanathan; S Gulyani; M Aldrich; M Cornford; J M Siegel
Journal: Neuron Date: 2000-09 Impact factor: 17.173

11 in total

1. Exclusive postsynaptic action of hypocretin-orexin on sublayer 6b cortical neurons.

Authors: Laurence Bayer; Mauro Serafin; Emmanuel Eggermann; Benoît Saint-Mleux; Danièle Machard; Barbara E Jones; Michel Mühlethaler
Journal: J Neurosci Date: 2004-07-28 Impact factor: 6.167

2. Glucagon regulates orexin A secretion in humans and rodents.

Authors: Ayman M Arafat; Przemysław Kaczmarek; Marek Skrzypski; Ewa Pruszyńska-Oszmałek; Paweł Kołodziejski; Aikaterini Adamidou; Stephan Ruhla; Dawid Szczepankiewicz; Maciej Sassek; Maria Billert; Bertram Wiedenmann; Andreas F H Pfeiffer; Krzysztof W Nowak; Mathias Z Strowski
Journal: Diabetologia Date: 2014-07-27 Impact factor: 10.122

Review 3. Diagnosis and management of sleep disorders in Prader-Willi syndrome.

Authors: Jessica Duis; Lara C Pullen; Maria Picone; Norman Friedman; Stephen Hawkins; Elise Sannar; Anna C Pfalzer; Althea Robinson Shelton; Deepan Singh; Phyllis C Zee; Daniel G Glaze; Amee Revana
Journal: J Clin Sleep Med Date: 2022-06-01 Impact factor: 4.324

4. Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice.

Authors: Mark S Blumberg; Cassandra M Coleman; Eric D Johnson; Cynthia Shaw
Journal: Eur J Neurosci Date: 2007-01 Impact factor: 3.386

5. Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men.

Authors: Hong Sun; William P Kennedy; Darren Wilbraham; Nicole Lewis; Nicole Calder; Xiaodong Li; Junshui Ma; Ka Lai Yee; Susan Ermlich; Eric Mangin; Christopher Lines; Laura Rosen; Jeffrey Chodakewitz; Gail M Murphy
Journal: Sleep Date: 2013-02-01 Impact factor: 5.849

6. Profiles of novel diurnally regulated genes in mouse hypothalamus: expression analysis of the cysteine and histidine-rich domain-containing, zinc-binding protein 1, the fatty acid-binding protein 7 and the GTPase, ras-like family member 11b.

Authors: J R Gerstner; W M Vander Heyden; T M Lavaute; C F Landry
Journal: Neuroscience Date: 2006-03-06 Impact factor: 3.590