Literature DB >> 11677139

The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.

J I Levin1, J M Chen, M T Du, F C Nelson, T Wehr, J F DiJoseph, L M Killar, S Skala, A Sung, M A Sharr, C E Roth, G Jin, R Cowling, L Di, M Sherman, Z B Xu, C J March, K M Mohler, R A Black, J S Skotnicki.   

Abstract

Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.

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Year:  2001        PMID： 11677139     DOI： 10.1016/s0960-894x(01)00601-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.

Authors:  Yasuhiko Kawasaki; Zhen-Zhong Xu; Xiaoying Wang; Jong Yeon Park; Zhi-Ye Zhuang; Ping-Heng Tan; Yong-Jing Gao; Kristine Roy; Gabriel Corfas; Eng H Lo; Ru-Rong Ji
Journal:  Nat Med       Date:  2008-02-10       Impact factor: 53.440

2.  Staphylococcal superantigen-like protein 5 inhibits matrix metalloproteinase 9 from human neutrophils.

Authors:  Saotomo Itoh; Eri Hamada; Go Kamoshida; Kana Takeshita; Teruaki Oku; Tsutomu Tsuji
Journal:  Infect Immun       Date:  2010-05-17       Impact factor: 3.441

3.  Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.

Authors:  Yuta Saito; Wakana Sekine; Rikio Sano; Shinya Komatsu; Hiromi Mizuno; Kouji Katabami; Kentaro Shimada; Teruaki Oku; Tsutomu Tsuji
Journal:  Clin Exp Metastasis       Date:  2010-03-30       Impact factor: 5.150

4.  Anthranilate derivatives as TACE inhibitors: docking based CoMFA and CoMSIA analyses.

Authors:  Malkeet Singh Bahia; Shravan Kumar Gunda; Shwetha Reddy Gade; Saikh Mahmood; Ravikumar Muttineni; Om Silakari
Journal:  J Mol Model       Date:  2010-03-28       Impact factor: 1.810

5.  First-in-Class Star-Shaped Triazine Dendrimers Endowed with MMP-9 Inhibition and VEGF Suppression Capacity: Design, Synthesis, and Anticancer Evaluation.

Authors:  Nesreen S Haiba; Hosam H Khalil; Ahmed Bergas; Marwa M Abu-Serie; Sherine N Khattab; Mohamed Teleb
Journal:  ACS Omega       Date:  2022-06-09

6.  Ligand-based pharmacophore modeling and molecular dynamic simulation approaches to identify putative MMP-9 inhibitors.

Authors:  Bharat Kumar Reddy Sanapalli; Vidyasrilekha Yele; Srikanth Jupudi; Veera Venkata Satyanarayana Reddy Karri
Journal:  RSC Adv       Date:  2021-08-06       Impact factor: 4.036
  6 in total

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