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Literature DB >> 1165108

Human chorionic gonadotropin. Its inhibitory effect on cell-mediated immunity in vivo and in vitro.

Abstract

An inhibitory effect of human chorionic gonadotropin (HCG) on delayed hypersensitivity skin test responses in guinea-pigs given 4000 i.u. of HCG intraperitoneally, 1--7 days prior to skin testing, is presented. The effect of HCG on skin test responses lasted for at least 3 weeks. Inhibition of lymphocyte response to PHA or PPD in the HCG-treated guinea-pigs was also observed. Guinea-pig peripheral blood lymphocyte response to mitogen or antigen is unequivocally inhibited by HCG in vitro. The effect of this hormone is not due to direct cytotoxicity, and its inhibitory effect seems to be dose related. These observations support the hypothesis that the HCG and possibly other placental hormones might play an important role in protecting the foetus against maternal rejection.

Entities: Disease Species

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Year: 1975 PMID： 1165108 PMCID： PMC1445967

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

15 in total

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Journal: Lancet Date: 1972-04-08 Impact factor: 79.321

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Journal: Lancet Date: 1971-11-13 Impact factor: 79.321

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Authors: S F Contractor; H Davies
Journal: Nat New Biol Date: 1973-06-27

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Journal: Br Med J Date: 1972-07-15

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Authors: S Kasakura
Journal: J Immunol Date: 1971-11 Impact factor: 5.422

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Journal: Nature Date: 1969-11-29 Impact factor: 49.962

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Authors: M D Kaye; W R Jones
Journal: Am J Obstet Gynecol Date: 1971-04-01 Impact factor: 8.661

10. Human chorionic gonadotropin: its possible role in maternal lymphocyte suppression.

Authors: E W Adcock; T Teasdale; C S August; S Cox; G Meschia; T C Ballaglia; M A Naughton
Journal: Science Date: 1973-08-31 Impact factor: 47.728

13 in total

1. Placental isoferritin as a physiological downregulator of cellular immunoreactivity during pregnancy.

Authors: L Sirota; B Kupfer; C Moroz
Journal: Clin Exp Immunol Date: 1989-08 Impact factor: 4.330

2. The effect of preparations of human chorionic gonadotropin on lymphocyte stimulation and immune response.

Authors: R F Maes; N Claverie
Journal: Immunology Date: 1977-09 Impact factor: 7.397

3. Effects of placental tissue on immunological responses.

Authors: M Barg; R C Burton; J A Smith; G A Luckenbach; J Decker; G F Mitchell
Journal: Clin Exp Immunol Date: 1978-12 Impact factor: 4.330

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Authors: J Plum; M Thiery; L Sabbe
Journal: Clin Exp Immunol Date: 1978-01 Impact factor: 4.330

5. Effects of short-term administration of human chorionic gonadotropin on immune functions in cryptorchid children.

Authors: M Maghnie; A Valtorta; A Moretta; D Larizza; M A Girani; F Severi
Journal: Eur J Pediatr Date: 1991-02 Impact factor: 3.183

6. Listeriosis in sheep. Experimental listeric infection in sheep treated with various immunosuppressiva.

Authors: H Grønstøl
Journal: Acta Vet Scand Date: 1980 Impact factor: 1.695

Review 7. Hepatitis E and pregnancy: understanding the pathogenesis.

Authors: Udayakumar Navaneethan; Mayar Al Mohajer; Mohamed T Shata
Journal: Liver Int Date: 2008-07-25 Impact factor: 5.828

8. Immunosuppression by human placenta lactogen (HPL) and the pregnancy-specific beta 1-glycoprotein (SP-1). Inhibition of mitogen-induced lymphocyte transformation.

Authors: C Cerni; G Tatra; H Bohn
Journal: Arch Gynakol Date: 1977-08-31

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Authors: C H Horne; C M Towler; R G Pugh-Humphreys; A W Thomson; H Bohn
Journal: Experientia Date: 1976-09-15

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Authors: H Bessler; L Sirota; F Dulitzky; M Djaldetti
Journal: Clin Exp Immunol Date: 1987-06 Impact factor: 4.330