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Literature DB >> 1164596

Comparative bioassay of prostaglandin E2 and its three pulmonary metabolites.

Abstract

The relative potencies of prostaglandin E2 and its metabolites 15-keto PGE2, 13,14-dihydro-15-keto-PGE2 and 13,14,dihydro-PGE2 were investigated on isolated smooth muscle preparations. These were rat stomach strip, colon and uterus, chick rectum, guinea-pig ileum, trachea and pulmonary artery and rabbit aorta and pulmonary artery. 15-keto PGE2 was equiactive or 1-1.8 times more potent than prostaglandin E2 in relaxing guinea-pig trachea but otherwise the three metabolites were less active than prostaglandin E2 on all preparations.

Entities: Chemical Disease Species

Mesh：

Substances：
Prostaglandins E

Year: 1975 PMID： 1164596 PMCID： PMC1666467 DOI： 10.1111/j.1476-5381.1975.tb07581.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

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Comparative bioassay of prostaglandin E2 and its three pulmonary metabolites.

1. PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.

2. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

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4. Potent bronchoconstrictor activity of 15-keto prostaglandin F2alpha.

5. Proceedings: Increased inactivation of prostaglandin E2 by the rabbit lung during pregnancy.

6. Inactivation of prostaglandins by the lungs.

7. The biological activities of three metabolites of prostaglandin E 1.

Review 1. Prostaglandin-mediated hypercalcemia: a paraneoplastic syndrome.

2. Bioassay and thin-layer chromatography of prostaglandins and their pulmonary metabolites [proceedings].

3. Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung.

4. Actions of prostaglandin E2 metabolites on skin microcirculation.

5. Introduction to the biosynthesis and metabolism of prostaglandins.

Review 6. Formation and degradation of prostaglandins in the lung.

7. Release of active substances during anaphylaxis.

8. Lack of release of prostaglandins from isolated perfused lungs during pulmonary hypertension and oedema.

9. Pathways of prostaglandin F2alpha metabolism in mammalian kidneys.

10. The catabolism of prostaglandins by rat skin.