Literature DB >> 1161050

Functional antagonism between calcium-antagonists and noradrenaline on isolated guinea-pig atria.

B D Görlitz, J Wagner, H J Schümann.   

Abstract

In the isolated electrically driven guinea-pig atrium the influence of D 600 and nifedipine on the action of noradrenaline was investigated. 1. The calcium-antagonists caused a dose-dependent negative inotropic effect. 10(-7) M of D 600 or nifedipine inhibited the contractile amplitude by 75 and 55%, respectively. 2. In spite of the pronounced negative inotropic effect evoked by the two calcium-antagonists, the maximal response to noradrenaline was not changed. The sensitivity of the myocardium to noradrenaline was only slightly diminished i.e. by a factor of 4.6 and 3 as calculated from the pD2-values. 3. The functional antagonism between noradrenaline and calcium-antagonists, therefore, offers the possibility to overcome cardiac side-effects of calcium-antagonists.

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Year:  1975        PMID： 1161050     DOI： 10.1007/bf00500536

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  11 in total

1.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors:  J M VAN ROSSUM
Journal:  Arch Int Pharmacodyn Ther       Date:  1963

2.  [BAY a 1040--a highly potent Ca ++ -antagonistic inhibitor of electro-mechanical coupling processes in mammalian myocardium].

Authors:  A Fleckenstein; H Tritthart; H J Döring; K Y Byon
Journal:  Arzneimittelforschung       Date:  1972-01

3.  [Acute action of nifedipine on the heart and circulation of dogs before and after oral long-term treatment].

Authors:  K van Ackern; W Braasch; U B Brückner; B Hakimi; J Schmier; I Simo
Journal:  Arzneimittelforschung       Date:  1974-10

4.  [Effect of nifedipine on the sympathetic nerve function of the heart].

Authors:  K Starke; H J Schümann
Journal:  Arzneimittelforschung       Date:  1973-02

5.  [Studies on nifedipine, a coronary vasodilator agent with rapid sublingual effects].

Authors:  W K Raff; F Kosche; W Lochner
Journal:  Arzneimittelforschung       Date:  1972-01

6.  [A new group of competitive divalent Ca-antagonists (iproveratril, D 600, prenylamine) with potent inhibitory effects on electromechanical coupling in mammalian myocardium].

Authors:  A Fleckenstein; H Tritthart; B Flackenstein; A Herbst; G Grün
Journal:  Pflugers Arch       Date:  1969       Impact factor: 3.657

7.  Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs.

Authors:  J Wagner; D Reinhardt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

8.  [Pharmacology of 4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (Nifedipine, BAY a 1040)].

Authors:  W Vater; G Kroneberg; F Hoffmeister; H Saller; K Meng; A Oberdorf; W Puls; K Schlossmann; K Stoepel
Journal:  Arzneimittelforschung       Date:  1972-01

9.  [Electromechanical uncoupling of vascular smooth muscle as the basic principle of coronary dilatation by 4-(2'-nitrophenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (BAY a 1040, Nifedipine). 1. The significance of Ca ++ ions for the bioelectrical and mechanical activity of smooth muscle].

Authors:  G Grün; A Fleckenstein
Journal:  Arzneimittelforschung       Date:  1972-02

10.  [Uterus relaxation by highly potent Ca plus,plus-antagonistic inhibitors of electro-mechanical coupling such as Isoptin (verapamil, iproveratril), compound D 600 and Segontin (prenylamine). Experiments on the isolated virgin rat uterus].

Authors:  A Fleckenstein; G Grün; H Tritthart; K Byon
Journal:  Klin Wochenschr       Date:  1971-01
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  2 in total

1.  Influence of papaverine, D600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit.

Authors:  H J Schümann; B D Görlitz; J Wagner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

2.  On the action of nifedipine under conditions of variable stimulation patterns and [Ca2+]0 in guinea-pig atrium.

Authors:  K Baumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-08       Impact factor: 3.000
  2 in total

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