Literature DB >> 1161061

Influence of papaverine, D600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit.

H J Schümann, B D Görlitz, J Wagner.   

Abstract

The effects of papaverine and of the organic calcium-antagonistic agents D 600 and nifedipine on the contraction induced by noradrenaline and calcium were studied on the isolated aorta and mesenteric artery. The affinities of both agonists, given as pD2-values, were significantly higher on the aorta than on the mesenteric artery. Under our experimental conditions D 600, nifedipine and papaverine were found to act as antagonists against calcium and noradrenaline in a non-competitive fashion. In either vessel, the calcium-antagonistic activity of D 600 and nifedipine was about 1000-fold greater than that of papaverine, whereas their antagonistic activity against noradrenaline was bout 1000-times weaker, i.e. D 600 as well as nifedipine were about equipotent with papaverine. The comparison between the calcium- and the noradrenaline-antagonistic activity offers the possiblity to evaluate the specifcity of calcium antagonistic agents.

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Year:  1975        PMID： 1161061     DOI： 10.1007/bf00508414

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  15 in total

1.  Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.

Authors:  R F FURCHGOTT; S BHADRAKOM
Journal:  J Pharmacol Exp Ther       Date:  1953-06       Impact factor: 4.030

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Journal:  J Pharm Pharmacol       Date:  1971-02       Impact factor: 3.765

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4.  [BAY a 1040--a highly potent Ca ++ -antagonistic inhibitor of electro-mechanical coupling processes in mammalian myocardium].

Authors:  A Fleckenstein; H Tritthart; H J Döring; K Y Byon
Journal:  Arzneimittelforschung       Date:  1972-01

5.  [Effect of nifedipine on the sympathetic nerve function of the heart].

Authors:  K Starke; H J Schümann
Journal:  Arzneimittelforschung       Date:  1973-02

6.  The absence of increased membrane calcium permeability during norepinephrine stimulation of arterial smooth muscle.

Authors:  C Van Breemen; P Lesser
Journal:  Microvasc Res       Date:  1971-01       Impact factor: 3.514

7.  [Studies on nifedipine, a coronary vasodilator agent with rapid sublingual effects].

Authors:  W K Raff; F Kosche; W Lochner
Journal:  Arzneimittelforschung       Date:  1972-01

8.  On the mechanism of action of some myolytic agents on depolarized guinea pig taenia coli.

Authors:  M Ferrari; F Carpenedo
Journal:  Arch Int Pharmacodyn Ther       Date:  1968-07

9.  Na-Ca exchange and tension development in arterial smooth muscle.

Authors:  H Reuter; M P Blaustein; G Haeusler
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1973-03-15       Impact factor: 6.237

10.  [Electromechanical uncoupling of vascular smooth muscle as the basic principle of coronary dilatation by 4-(2'-nitrophenyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (BAY a 1040, Nifedipine). 1. The significance of Ca ++ ions for the bioelectrical and mechanical activity of smooth muscle].

Authors:  G Grün; A Fleckenstein
Journal:  Arzneimittelforschung       Date:  1972-02
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  14 in total

Review 1.  Ca-exchange, Ca-channels and Ca-antagonists.

Authors:  G Droogmans; B Himpens; R Casteels
Journal:  Experientia       Date:  1985-07-15

2.  Effects of tetrandrine on various vascular smooth muscles.

Authors:  W S Hu; Z H Zhou; C J Hu; F H Lu
Journal:  J Tongji Med Univ       Date:  1986

3.  Studies on the mechanism of action of various vasodilators.

Authors:  G Gagnon; D Regoli; F Rioux
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739

4.  Tissue response selectivity of calcium antagonists is not due to heterogeneity of [3H]-nitrendipine binding sites.

Authors:  M R Bristow; R Ginsburg; J A Laser; B J McAuley; W Minobe
Journal:  Br J Pharmacol       Date:  1984-06       Impact factor: 8.739

5.  Kinetics of acetylcholine-activated cation channel blockade by the calcium antagonist D-600 in Aplysia neurons.

Authors:  N T Slater; H L Haas; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1983-12       Impact factor: 5.046

6.  Effects of five different organic calcium antagonists on guinea-pig isolated trachea.

Authors:  C Advenier; J Cerrina; P Duroux; A Floch; A Renier
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

7.  (+)-S-12967 and (-)-S-12968: 1,4-dihydropyridine stereoisomers with calcium channel agonistic and antagonistic properties in rat resistance arteries.

Authors:  D Prieto; M J Mulvany; N C Nyborg
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

8.  Effects of some organic calcium antagonists and other procedures affecting Ca2+ Translocation on KCl-induced contractions in the rat vas deferens.

Authors:  D W Hay; R M Wadsworth
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

9.  Some effects of sodium nitroprusside, methoxyverapamil (D600) and nifedipine on rat portal vein.

Authors:  M Jetley; A H Weston
Journal:  Br J Pharmacol       Date:  1980-02       Impact factor: 8.739

Review 10.  Calcium antagonists. Pharmacodynamic effects and mechanism of action.

Authors:  T T Zsotér; J G Church
Journal:  Drugs       Date:  1983-02       Impact factor: 9.546
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