Literature DB >> 11606750

Deamidation of human proteins.

N E Robinson1, A B Robinson.   

Abstract

Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.

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Year:  2001        PMID： 11606750      PMCID： PMC60067          DOI： 10.1073/pnas.221463198

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Mass spectrometric evaluation of synthetic peptides as primary structure models for peptide and protein deamidation.

Authors:  N E Robinson; A B Robinson; R B Merrifield
Journal:  J Pept Res       Date:  2001-06

2.  Posttranslational deamidation of proteins: the case of hemoglobin J Sardegna [alpha50(CD8)His-->Asn-->Asp].

Authors:  R Paleari; E Paglietti; A Mosca; M Mortarino; L Maccioni; S Satta; A Cao; R Galanello
Journal:  Clin Chem       Date:  1999-01       Impact factor: 8.327

3.  Molecular clocks.

Authors:  N E Robinson; A B Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

4.  Multiple forms of cytochrome c in the rat. Precursor-product relationship between the main component Cy I and the minor components Cy II and Cy 3 in vivo.

Authors:  T Flatmark; K Sletten
Journal:  J Biol Chem       Date:  1968-04-10       Impact factor: 5.157

5.  The specific nonenzymatic cleavage of bovine ribonuclease with hydroxylamine.

Authors:  P Bornstein; G Balian
Journal:  J Biol Chem       Date:  1970-09-25       Impact factor: 5.157

6.  Kinetic study of the deamidation of growth hormone and prolactin.

Authors:  U J Lewis; E V Cheever; W C Hopkins
Journal:  Biochim Biophys Acta       Date:  1970-09-29

7.  Prediction of protein deamidation rates from primary and three-dimensional structure.

Authors:  N E Robinson; A B Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

8.  Effect of the three-dimensional structure on the deamidation reaction of ribonuclease A.

Authors:  S Capasso; S Salvadori
Journal:  J Pept Res       Date:  1999-11

9.  Microheterogeneity of recombinant human phenylalanine hydroxylase as a result of nonenzymatic deamidations of labile amide containing amino acids. Effects on catalytic and stability properties.

Authors:  T Solstad; T Flatmark
Journal:  Eur J Biochem       Date:  2000-10

10.  Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer.

Authors:  A B Robinson; J H McKerrow; P Cary
Journal:  Proc Natl Acad Sci U S A       Date:  1970-07       Impact factor: 11.205
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  73 in total

1.  Protein deamidation.

Authors:  Noah E Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

2.  Deamidation accelerates amyloid formation and alters amylin fiber structure.

Authors:  Emily B Dunkelberger; Lauren E Buchanan; Peter Marek; Ping Cao; Daniel P Raleigh; Martin T Zanni
Journal:  J Am Chem Soc       Date:  2012-07-17       Impact factor: 15.419

Review 3.  Stability of IgG isotypes in serum.

Authors:  Ivan R Correia
Journal:  MAbs       Date:  2010-05-16       Impact factor: 5.857

4.  A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain.

Authors:  Sarah B Scruggs; Rick Reisdorph; Mike L Armstrong; Chad M Warren; Nichole Reisdorph; R John Solaro; Peter M Buttrick
Journal:  Mol Cell Proteomics       Date:  2010-05-05       Impact factor: 5.911

5.  Are ancient proteins responsible for the age-related decline in health and fitness?

Authors:  Roger John Willis Truscott
Journal:  Rejuvenation Res       Date:  2010-02       Impact factor: 4.663

6.  Mapping site-specific changes that affect stability of the N-terminal domain of calmodulin.

Authors:  Mary E Krause; Talia T Martin; Jennifer S Laurence
Journal:  Mol Pharm       Date:  2012-02-15       Impact factor: 4.939

7.  Accurate identification of deamidated peptides in global proteomics using a quadrupole orbitrap mass spectrometer.

Authors:  Angelito I Nepomuceno; Radiance J Gibson; Shan M Randall; David C Muddiman
Journal:  J Proteome Res       Date:  2013-12-12       Impact factor: 4.466

8.  Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice.

Authors:  Shujia Dai; Wenqin Ni; Alexander N Patananan; Steven G Clarke; Barry L Karger; Zhaohui Sunny Zhou
Journal:  Anal Chem       Date:  2013-02-06       Impact factor: 6.986

9.  Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state.

Authors:  Bei Li; Richard L Schowen; Elizabeth M Topp; Ronald T Borchardt
Journal:  AAPS J       Date:  2006-03-20       Impact factor: 4.009

Review 10.  Protein homeostasis: live long, won't prosper.

Authors:  Brandon H Toyama; Martin W Hetzer
Journal:  Nat Rev Mol Cell Biol       Date:  2013-01       Impact factor: 94.444
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