Literature DB >> 11603256

Fatal overdose with trazodone: case report and literature review.

A de Meester1, G Carbutti, L Gabriel, J M Jacques.   

Abstract

A fatal case of suicide with trazodone alone in a 40-year-old patient is reported. Life-threatening arrhythmias, such as torsades de pointes and complete AV block, are recorded. Blood collected at admission contained a trazodone toxic concentration of 25.4 micrograms/mL. The patient developed multiple organ failure and died less than 24 hours after his admission to the emergency department. The authors discuss the effects of overdose of trazodone, a well-known safe antidepressant drug.

Entities:  

Mesh:

Substances:

Year:  2001        PMID: 11603256     DOI: 10.1179/acb.2001.038

Source DB:  PubMed          Journal:  Acta Clin Belg        ISSN: 1784-3286            Impact factor:   1.264


  11 in total

Review 1.  The QT interval and psychotropic medications in children: recommendations for clinicians.

Authors:  Paul McNally; Fiona McNicholas; Paul Oslizlok
Journal:  Eur Child Adolesc Psychiatry       Date:  2006-08-29       Impact factor: 4.785

2.  Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry.

Authors:  Sarah M R Wille; Els A De Letter; Michel H A Piette; Lien K Van Overschelde; Carlos H Van Peteghem; Willy E Lambert
Journal:  Int J Legal Med       Date:  2008-10-07       Impact factor: 2.686

3.  Drug-specific risk of severe QT prolongation following acute drug overdose.

Authors:  Sharan L Campleman; Jeffery Brent; Anthony F Pizon; Joshua Shulman; Paul Wax; Alex F Manini
Journal:  Clin Toxicol (Phila)       Date:  2020-04-07       Impact factor: 4.467

4.  Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.

Authors:  Edgar Zitron; Claudia Kiesecker; Eberhard Scholz; Sonja Lück; Ramona Bloehs; Sven Kathöfer; Dierk Thomas; Johann Kiehn; Volker A W Kreye; Hugo A Katus; Wolfgang Schoels; Christoph A Karle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-07-29       Impact factor: 3.000

Review 5.  Trazodone and omeprazole interaction causing frequent second-degree Mobitz type 1 atrioventricular (AV) block (Wenckebach phenomenon) and syncope: a case report and literature review.

Authors:  Oluwaseun A Akinseye; Mostafa Alfishawy; Farshid Radparvar; Sanjiv Bakshi
Journal:  Am J Case Rep       Date:  2015-05-27

6.  Arrhythmias in Severe Trazodone Overdose.

Authors:  Kyaw Khaing Soe; Mark Young Lee
Journal:  Am J Case Rep       Date:  2019-12-27

7.  Comparison of LC-MS and LC-DAD Methods of Detecting Abused Piperazine Designer Drugs.

Authors:  Anna Welz; Marcin Koba; Piotr Kośliński; Joanna Siódmiak
Journal:  J Clin Med       Date:  2022-03-22       Impact factor: 4.241

Review 8.  Rediscovering trazodone for the treatment of major depressive disorder.

Authors:  Andrea Fagiolini; Alessandro Comandini; Mario Catena Dell'Osso; Siegfried Kasper
Journal:  CNS Drugs       Date:  2012-12       Impact factor: 5.749

9.  A Case of Trazodone Overdose Successfully Rescued With Lipid Emulsion Therapy.

Authors:  Roger Taylor; Joshua Burg; Jeff Mullen
Journal:  Cureus       Date:  2020-10-09

10.  Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects.

Authors:  Valeria Tellone; Maria Teresa Rosignoli; Rossella Picollo; Patrizia Dragone; Alessandra Del Vecchio; Alessandro Comandini; Milko Radicioni; Chiara Leuratti; Fabrizio Calisti
Journal:  J Clin Pharmacol       Date:  2020-06-02       Impact factor: 3.126

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.