Literature DB >> 11600384

Synergistic activities of gatifloxacin in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species.

E Gradelski1, L Valera, D Bonner, J Fung-Tomc.   

Abstract

Drug combinations have been used to treat serious infections caused by Pseudomonas, Burkholderia, Stenotrophomonas, and Acinetobacter. In this study, the combined drug effects of gatifloxacin (GAT) and nonquinolones were determined by time-kill analysis at clinically achievable drug concentrations. Synergy (>or=2 log(10)-enhanced killing at 24 h) was observed with GAT plus amikacin or a beta-lactam against 50 to 75% of strains, including strains nonsusceptible to one or both drugs.

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Year:  2001        PMID： 11600384      PMCID： PMC90810          DOI： 10.1128/AAC.45.11.3220-3222.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Comparative killing rates of fluoroquinolones and cell wall-active agents.

Authors:  J C Fung-Tomc; E Gradelski; L Valera; B Kolek; D P Bonner
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

Review 2.  Synergy and antagonism of combinations with quinolones.

Authors:  H C Neu
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-04       Impact factor: 3.267

3.  In vitro activity of aztreonam, cefotaxime, ceftazidime and imipenem combined with ciprofloxacin against gram-negative bacilli and compared with amikacin combinations against Pseudomonas aeruginosa.

Authors:  M Díez Enciso
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

4.  In vitro antibacterial spectrum of a new broad-spectrum 8-methoxy fluoroquinolone, gatifloxacin.

Authors:  J Fung-Tomc; B Minassian; B Kolek; T Washo; E Huczko; D Bonner
Journal:  J Antimicrob Chemother       Date:  2000-04       Impact factor: 5.790

5.  Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method.

Authors:  H O Hallander; K Dornbusch; L Gezelius; K Jacobson; I Karlsson
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

6.  Ciprofloxacin interactions with imipenem and amikacin against multiresistant Pseudomonas aeruginosa.

Authors:  H Giamarellou; G Petrikkos
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

Review 7.  Synergy of fluoroquinolones with other antimicrobial agents.

Authors:  H C Neu
Journal:  Rev Infect Dis       Date:  1989 Jul-Aug

8.  Evaluation of ciprofloxacin's synergism with other agents by multiple in vitro methods.

Authors:  J A Moody; D N Gerding; L R Peterson
Journal:  Am J Med       Date:  1987-04-27       Impact factor: 4.965

9.  Activities of three quinolones, alone and in combination with extended-spectrum cephalosporins or gentamicin, against Stenotrophomonas maltophilia.

Authors:  M A Visalli; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

10.  Synergy of ciprofloxacin and azlocillin in vitro and in a neutropenic mouse model of infection.

Authors:  N X Chin; K Jules; H C Neu
Journal:  Eur J Clin Microbiol       Date:  1986-02       Impact factor: 3.267
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Journal:  Evid Based Complement Alternat Med       Date:  2022-05-09       Impact factor: 2.650

2.  Synergistic antibacterial effect between silybin and N,N'-dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates.

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Journal:  J Microbiol       Date:  2008-08-31       Impact factor: 3.422

3.  Isoflavonoid-Antibiotic Thin Films Fabricated by MAPLE with Improved Resistance to Microbial Colonization.

Authors:  Valentina Grumezescu; Irina Negut; Rodica Cristescu; Alexandru Mihai Grumezescu; Alina Maria Holban; Florin Iordache; Mariana Carmen Chifiriuc; Roger J Narayan; Douglas B Chrisey
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