Literature DB >> 11600381

In vitro killing of Candida albicans by fatty acids and monoglycerides.

G Bergsson1, J Arnfinnsson, H Thormar.   

Abstract

The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

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Year:  2001        PMID： 11600381      PMCID： PMC90807          DOI： 10.1128/AAC.45.11.3209-3212.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

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