Literature DB >> 11600378

Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.

M Shimizu1, S Shiota, T Mizushima, H Ito, T Hatano, T Yoshida, T Tsuchiya.   

Abstract

We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of beta-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

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Year:  2001        PMID： 11600378      PMCID： PMC90804          DOI： 10.1128/AAC.45.11.3198-3201.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

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