Literature DB >> 11598102

Naturally occurring Clostridium perfringens nontoxic alpha-toxin variant as a potential vaccine candidate against alpha-toxin-associated diseases.

H Schoepe1, C Pache, A Neubauer, H Potschka, T Schlapp, L H Wieler, G Baljer.   

Abstract

Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable. Vaccination with this genetically constructed alpha-toxin variant, rAT121/91, induces antibodies capable of significantly reducing activities induced by wild-type toxin. Thus, rAT121/91 could be a useful vaccine candidate.

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Year:  2001        PMID： 11598102      PMCID： PMC100128          DOI： 10.1128/IAI.69.11.7194-7196.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

1.  Cloning and sequencing of a phospholipase C gene of Clostridium perfringens.

Authors:  A Okabe; T Shimizu; H Hayashi
Journal:  Biochem Biophys Res Commun       Date:  1989-04-14       Impact factor: 3.575

Review 2.  Bacterial phospholipases C.

Authors:  R W Titball
Journal:  Microbiol Rev       Date:  1993-06

3.  An egg-yolk agar diffusion assay for monitoring phospholipase C in cultures of Clostridium welchii.

Authors:  G J Rigby
Journal:  J Appl Bacteriol       Date:  1981-02

4.  Cloning and expression of the phospholipase C gene from Clostridium perfringens and Clostridium bifermentans.

Authors:  J Y Tso; C Siebel
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

5.  Molecular cloning and nucleotide sequence of the alpha-toxin (phospholipase C) of Clostridium perfringens.

Authors:  R W Titball; S E Hunter; K L Martin; B C Morris; A D Shuttleworth; T Rubidge; D W Anderson; D C Kelly
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

6.  Gene cloning shows the alpha-toxin of Clostridium perfringens to contain both sphingomyelinase and lecithinase activities.

Authors:  B Saint-Joanis; T Garnier; S T Cole
Journal:  Mol Gen Genet       Date:  1989-11

7.  Controlled multiplex PCR of enterotoxigenic Clostridium perfringens strains in food samples.

Authors:  H Schoepe; H Potschka; T Schlapp; J Fiedler; H Schau; G Baljer
Journal:  Mol Cell Probes       Date:  1998-12       Impact factor: 2.365

8.  A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene.

Authors:  E D Williamson; R W Titball
Journal:  Vaccine       Date:  1993-09       Impact factor: 3.641

9.  Use of the tetracycline promoter for the tightly regulated production of a murine antibody fragment in Escherichia coli.

Authors:  A Skerra
Journal:  Gene       Date:  1994-12-30       Impact factor: 3.688

10.  Synthesis and evaluation of a non-radioactive gene probe for the detection of C.perfringens alpha toxin.

Authors:  T Schlapp; I Blaha; R Bauerfeind; L H Wieler; H Schoepe; R Weiss; G Baljer
Journal:  Mol Cell Probes       Date:  1995-04       Impact factor: 2.365
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  7 in total

1.  In vivo studies of Clostridium perfringens in mouse gas gangrene model.

Authors:  Nabonita Sengupta; Syed Imteyaz Alam
Journal:  Curr Microbiol       Date:  2010-11-19       Impact factor: 2.188

2.  Comparative proteomic analysis of extracellular proteins of Clostridium perfringens type A and type C strains.

Authors:  Nabonita Sengupta; Syed Imteyaz Alam; Bhoj Kumar; Ravi Bhushan Kumar; Vandana Gautam; Subodh Kumar; Lokendra Singh
Journal:  Infect Immun       Date:  2010-07-06       Impact factor: 3.441

Review 3.  Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines.

Authors:  Marcos Roberto A Ferreira; Gustavo Marçal S G Moreira; Carlos Eduardo P da Cunha; Marcelo Mendonça; Felipe M Salvarani; Ângela N Moreira; Fabricio R Conceição
Journal:  Toxins (Basel)       Date:  2016-11-21       Impact factor: 4.546

4.  Gene expression profiling within the spleen of Clostridium perfringens-challenged broilers fed antibiotic-medicated and non-medicated diets.

Authors:  Aimie J Sarson; Ying Wang; Zhumei Kang; Scot E Dowd; Yang Lu; Hai Yu; Yanming Han; Huaijun Zhou; Joshua Gong
Journal:  BMC Genomics       Date:  2009-06-07       Impact factor: 3.969

5.  The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis.

Authors:  Evy Goossens; Stefanie Verherstraeten; Bonnie R Valgaeren; Bart Pardon; Leen Timbermont; Stijn Schauvliege; Diego Rodrigo-Mocholí; Freddy Haesebrouck; Richard Ducatelle; Piet R Deprez; Filip Van Immerseel
Journal:  Vet Res       Date:  2016-04-27       Impact factor: 3.683

6.  Selection of Bacillus spp. for Cellulase and Xylanase Production as Direct-Fed Microbials to Reduce Digesta Viscosity and Clostridium perfringens Proliferation Using an in vitro Digestive Model in Different Poultry Diets.

Authors:  Juan D Latorre; Xochitl Hernandez-Velasco; Vivek A Kuttappan; Ross E Wolfenden; Jose L Vicente; Amanda D Wolfenden; Lisa R Bielke; Omar F Prado-Rebolledo; Eduardo Morales; Billy M Hargis; Guillermo Tellez
Journal:  Front Vet Sci       Date:  2015-08-17

7.  Evaluation of the Epithelial Barrier Function and Ileal Microbiome in an Established Necrotic Enteritis Challenge Model in Broiler Chickens.

Authors:  Juan D Latorre; Bishnu Adhikari; Si H Park; Kyle D Teague; Lucas E Graham; Brittany D Mahaffey; Mikayla F A Baxter; Xochitl Hernandez-Velasco; Young M Kwon; Steven C Ricke; Lisa R Bielke; Billy M Hargis; Guillermo Tellez
Journal:  Front Vet Sci       Date:  2018-08-21
  7 in total

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