| Literature DB >> 11597783 |
Y Iwase1, Y Takemura, M Ju-ichi, T Mukainaka, E Ichiishi, C Ito, H Furukawa, M Yano, H Tokuda, H Nishino.
Abstract
To search for possible anti-tumor promoters, ten flavonoid derivatives (1-10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11597783 DOI： 10.1016/s0304-3835(01)00615-2
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679