Literature DB >> 115960

Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses.

J Z Weinberger, B Benacerraf, M E Dorf.   

Abstract

The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T-cell mediated, delayed-type hypersensitivity (DTH) responses. It was shown that nitrophenyl acetyl-poly-(L-glu56-L-lys35-L-phe9) (NP-GLO) could prime for NP responses only in strains of mice which are Ir gene responders to GLO. In contrast to this requirement, NO-GLO could elicit an NP-specific response in NP-bovine gamma globulin primed mice, even in GLO nonresponder strains. Furthermore, the nonimmunogenic molecule, NP-GL, could elicit an NP-specific DTH response in animals primed with NP on an immunogenic carrier.

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Year:  1979        PMID： 115960      PMCID： PMC2185691          DOI： 10.1084/jem.150.5.1255

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  5 in total

Review 1.  The immune response genes of the major histocompatibility complex.

Authors:  B Benacerraf; R N Germain
Journal:  Immunol Rev       Date:  1978       Impact factor: 12.988

2.  H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.

Authors:  J F Miller; M A Vadas; A Whitelaw; J Gamble
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

3.  Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A-region genes.

Authors:  J Z Weinberger; M I Greene; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

4.  STUDIES ON ARTIFICIAL ANTIGENS. II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-ALPHA-AMINO ACIDS.

Authors:  B BENACERRAF; A OJEDA; P H MAURER
Journal:  J Exp Med       Date:  1963-12-01       Impact factor: 14.307

5.  Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell interactions to determinants linked together: suppression vs. enhancement.

Authors:  W W Bullock; D H Katz; B Benacerraf
Journal:  J Exp Med       Date:  1975-08-01       Impact factor: 14.307
  5 in total
  4 in total

1.  Mechanisms of genetic control of immune responses. II. Nonresponsiveness in BALB/c GT-specific cell-mediated immune responses does not correlate with the absence of functional T cells or the induction of suppressor T cells.

Authors:  M K Kennedy; M K Jenkins; S D Miller
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.

Authors:  D H Sherr; S T Ju; J Z Weinberger; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307

3.  Antigen-specific helper T cells required for dominant production of an idiotype (THId) are not under immune response (Ir) gene control.

Authors:  K Bottomly; P H Maurer
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307

4.  Hapten-specific T cell lines mediating delayed hypersensitivity to contact-sensitizing agents.

Authors:  W R Thomas; P L Mottram; J F Miller
Journal:  J Exp Med       Date:  1982-07-01       Impact factor: 14.307
  4 in total

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