| Literature DB >> 11595281 |
P Calvo1, B Gouritin, I Brigger, C Lasmezas, J Deslys, A Williams, J P Andreux, D Dormont, P Couvreur.
Abstract
PEGylated polymeric nanoparticles are hereby presented as a potential efficient drug carrier for the delivery of active therapeutic molecules in prion experimental diseases. Based on their blood long-circulating characteristics, these PEGylated particles made by the amphiphilic copolymer poly [methoxy poly(ethylene glycol) cyanoacrylate-co-hexadecyl cyanoacrylate] (PEG-PHDCA), showed comparatively conventional non-PEGylated nanoparticles, a higher uptake by the spleen and the brain which are both the target tissues of PrPres accumulation in scrapie infected animals.Entities:
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Year: 2001 PMID: 11595281 DOI: 10.1016/s0165-0270(01)00450-2
Source DB: PubMed Journal: J Neurosci Methods ISSN: 0165-0270 Impact factor: 2.390