Literature DB >> 11595178

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

G L Semenza1.   

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

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Year:  2001        PMID： 11595178     DOI： 10.1016/s0092-8674(01)00518-9

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  280 in total

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