OBJECTIVE: To examine the in vivo accuracy and precision of magnetic resonance imaging (MRI)-based assessment of cartilage loss in patients with severe osteoarthritis (OA) of the knee. METHODS: High-resolution MRI images of the tibial cartilage were obtained in 8 patients prior to total knee arthroplasty, using a water-excitation gradient-echo MRI sequence (acquisition time 6 minutes 19 seconds; spatial resolution 1.2 x 0.31 x 0.31 mm3). The MRI measurements were repeated after joint repositioning. The precision of the cartilage volume and thickness computations was determined after 3-dimensional reconstruction. During surgery, the tibial plateaus were resected, and the MRI data were compared with water displacement of surgically retrieved cartilage. RESULTS: The standard deviation (coefficient of variation) of repeated tibial cartilage volume measurements was 56 mm3 (5.5%) medially and 59 mm3 (3.8%) laterally. The deviation from surgically removed tissue was -13%, on average, with a high linear correlation between both methods (r = 0.98). In patients with varus OA, the tissue loss was estimated to be 1,290 mm3 in the medial tibia and 1,150 mm3 in the lateral tibia, compared with the data in healthy volunteers. CONCLUSION: Noninvasive quantitative MRI-based analysis of cartilage morphometry in severe OA is accurate, precise, and displays high potential diagnostic value.
OBJECTIVE: To examine the in vivo accuracy and precision of magnetic resonance imaging (MRI)-based assessment of cartilage loss in patients with severe osteoarthritis (OA) of the knee. METHODS: High-resolution MRI images of the tibial cartilage were obtained in 8 patients prior to total knee arthroplasty, using a water-excitation gradient-echo MRI sequence (acquisition time 6 minutes 19 seconds; spatial resolution 1.2 x 0.31 x 0.31 mm3). The MRI measurements were repeated after joint repositioning. The precision of the cartilage volume and thickness computations was determined after 3-dimensional reconstruction. During surgery, the tibial plateaus were resected, and the MRI data were compared with water displacement of surgically retrieved cartilage. RESULTS: The standard deviation (coefficient of variation) of repeated tibial cartilage volume measurements was 56 mm3 (5.5%) medially and 59 mm3 (3.8%) laterally. The deviation from surgically removed tissue was -13%, on average, with a high linear correlation between both methods (r = 0.98). In patients with varus OA, the tissue loss was estimated to be 1,290 mm3 in the medial tibia and 1,150 mm3 in the lateral tibia, compared with the data in healthy volunteers. CONCLUSION: Noninvasive quantitative MRI-based analysis of cartilage morphometry in severe OA is accurate, precise, and displays high potential diagnostic value.
Authors: F Eckstein; W Wirth; D J Hunter; A Guermazi; C K Kwoh; D R Nelson; O Benichou Journal: Osteoarthritis Cartilage Date: 2010-02-18 Impact factor: 6.576
Authors: Frank W Roemer; Ali Guermazi; John A Lynch; Charles G Peterfy; Michael C Nevitt; Nita Webb; Jing Li; Andreas Mohr; Harry K Genant; David T Felson Journal: Eur Radiol Date: 2005-01-05 Impact factor: 5.315
Authors: Jan-Ton A D van der Woude; Karen Wiegant; Peter M van Roermund; Femke Intema; Roel J H Custers; Felix Eckstein; Jaap M van Laar; Simon C Mastbergen; Floris P J G Lafeber Journal: Cartilage Date: 2016-08-26 Impact factor: 4.634
Authors: Andrea S Doria; Ningning Zhang; Bjorn Lundin; Pamela Hilliard; Carina Man; Ruth Weiss; Gary Detzler; Victor Blanchette; Rahim Moineddin; Felix Eckstein; Marshall S Sussman Journal: Pediatr Radiol Date: 2014-02-13
Authors: Felix Eckstein; Martin Hudelmaier; September Cahue; Meredith Marshall; Leena Sharma Journal: Calcif Tissue Int Date: 2009-01-16 Impact factor: 4.333