Literature DB >> 11591573

Contrast microbubbles improve diagnostic yield in ICU patients with poor echocardiographic windows.

T T Nguyen1, M R Dhond, R Sabapathy, W J Bommer.   

Abstract

OBJECTIVE: To determine the value of contrast echocardiographic studies in patients admitted to ICUs who have poor echocardiographic windows secondary to COPD, ventilator use, or inability to obtain optimal positioning for the echocardiogram.
DESIGN: A prospective comparison study of technically difficult patients in the ICU. OUTCOME MEASURE: The total scores for the left ventricle (LV) in the two-chamber and four-chamber views were calculated at baseline and following injection of 1 to 2 mL of a contrast agent. The mean numbers of segments visualized in all patients at baseline and after injection of contrast agent were compared to assess the effect on improved visualization.
RESULTS: Forty consecutive patients underwent echocardiography in the ICU for evaluation of LV function. Of these, 25 patients (63%) had poor visualization of the endocardium and required IV contrast agent. In these 25 patients, the average baseline segmental score was 4.5, compared to 11.6 in patients who received an IV contrast agent. Nineteen patients had an average baseline segmental score of 3.9 and were deemed to have a nondiagnostic study. After administration of IV contrast, all patients converted to a diagnostic study, with an average score of 11.6 segments visualized.
CONCLUSIONS: Use of echocardiographic contrast agents in selected patients with poor baseline echocardiographic windows in the ICU setting significantly enhances segmental LV visualization and yielded 100% conversion from nondiagnostic to diagnostic studies.

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Year:  2001        PMID: 11591573     DOI: 10.1378/chest.120.4.1287

Source DB:  PubMed          Journal:  Chest        ISSN: 0012-3692            Impact factor:   9.410


  6 in total

Review 1.  Echocardiography in the critically ill: current and potential roles.

Authors:  S Price; E Nicol; D G Gibson; T W Evans
Journal:  Intensive Care Med       Date:  2005-11-16       Impact factor: 17.440

2.  Clinical application and laboratory protocols for performing contrast echocardiography.

Authors:  Adrian Chong; Brian Haluska; Sudhir Wahi
Journal:  Indian Heart J       Date:  2013-04-06

3.  Safety of Perflutren Ultrasound Contrast Agents: A Disproportionality Analysis of the US FAERS Database.

Authors:  Manfred Hauben; Eric Y Hung; Kelly C Hanretta; Sripal Bangalore; Vincenza Snow
Journal:  Drug Saf       Date:  2015-11       Impact factor: 5.606

4.  Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit.

Authors:  David G Platts; Charles McDonald; Kiran Shekar; Darryl J Burstow; Daniel Mullany; Marc Ziegenfuss; Sara Diab; John F Fraser
Journal:  Intensive Care Med Exp       Date:  2016-03-11

5.  Echocardiographic assessment of myocardial function and mechanics during veno-venous extracorporeal membrane oxygenation.

Authors:  David G Platts; Kenji Shiino; Jonathan Chan; Darryl J Burstow; Gregory M Scalia; John F Fraser
Journal:  Echo Res Pract       Date:  2019-06-01

6.  Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop.

Authors:  David G Platts; Nicole Bartnikowski; Shaun D Gregory; Gregory M Scalia; John F Fraser
Journal:  Biomed Res Int       Date:  2017-08-13       Impact factor: 3.411

  6 in total

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