Literature DB >> 11591500

N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents.

T L Huang1, B Tao, Y Quarshie, S F Queener, I O Donkor.   

Abstract

The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 microM concentrations.

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Year:  2001        PMID： 11591500     DOI： 10.1016/s0960-894x(01)00541-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

Authors:  Michael L Berger; Dorota Maciejewska; Jean Jacques Vanden Eynde; Madhusoodanan Mottamal; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Ivana Jarak; Ivo Piantanida; Grace Karminski-Zamola; Annie Mayence; Patrick Rebernik; Arvind Kumar; Mohamed A Ismail; David W Boykin; Tien L Huang
Journal:  Bioorg Med Chem       Date:  2015-06-14       Impact factor: 3.641

2.  Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.

Authors:  Tien L Huang; Jean Jacques Vanden Eynde; Annie Mayence; Margaret S Collins; Melanie T Cushion; Donna Rattendi; Indira Londono; Lakshman Mazumder; Cyrus J Bacchi; Nigel Yarlett
Journal:  Bioorg Med Chem Lett       Date:  2009-08-23       Impact factor: 2.823

3.  HIV chromatin is a preferred target for drugs that bind in the DNA minor groove.

Authors:  Clayton K Collings; Donald W Little; Samuel J Schafer; John N Anderson
Journal:  PLoS One       Date:  2019-12-30       Impact factor: 3.240
  3 in total

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