Y R Smith1, J K Zubieta. 1. University of Michigan, Department of Obstetrics and Gynecology, Women's Hospital, Ann Arbor, Michigan 48109-0276, USA. ysmith@umich.edu
Abstract
OBJECTIVE: To review the literature on neuroimaging studies focusing on gender differences in the aging process and on the effects of postmenopausal estrogen use on the brain. DESIGN: Pertinent studies were identified through a computer MEDLINE search. References of selected articles were hand-searched for additional citations. CONCLUSION(S): The current literature suggests that estrogen replacement may decrease brain white matter lesions, increase cerebral blood flow, alter regional brain activation patterns during cognitive processing, and have modulatory effects on various neurotransmitter systems. Overall, this points to a functional plasticity in higher order brain processing that can be altered by gonadal steroids.
OBJECTIVE: To review the literature on neuroimaging studies focusing on gender differences in the aging process and on the effects of postmenopausal estrogen use on the brain. DESIGN: Pertinent studies were identified through a computer MEDLINE search. References of selected articles were hand-searched for additional citations. CONCLUSION(S): The current literature suggests that estrogen replacement may decrease brain white matter lesions, increase cerebral blood flow, alter regional brain activation patterns during cognitive processing, and have modulatory effects on various neurotransmitter systems. Overall, this points to a functional plasticity in higher order brain processing that can be altered by gonadal steroids.
Authors: Yolanda R Smith; Tiffany Love; Carol C Persad; Anne Tkaczyk; Thomas E Nichols; Jon-Kar Zubieta Journal: J Clin Endocrinol Metab Date: 2006-08-15 Impact factor: 5.958
Authors: Kathleen Ford; Maryfran Sowers; Teresa E Seeman; Gail A Greendale; Barbara Sternfeld; Susan A Everson-Rose Journal: Gerontology Date: 2009-10-10 Impact factor: 5.140
Authors: Natalie L Rasgon; Heather A Kenna; Tonita E Wroolie; Ryan Kelley; Daniel Silverman; John Brooks; Katherine E Williams; Bevin N Powers; Joachim Hallmayer; Allan Reiss Journal: Neurobiol Aging Date: 2009-12-23 Impact factor: 4.673