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Literature DB >> 21048520

BOLD signal response to cocaine varies with sexual receptivity in female rats.

Marcelo Febo¹, Annabell C Segarra, Tara L Stolberg, Craig F Ferris.

Abstract

Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a greater activation of mesolimbic and nigrostriatal structures than lordotic female rats. Our data suggest that the differential sensitivity to cocaine occurs not only as a result of hormonal changes of the estrous cycle, but also in association with changes in sexual receptivity.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21048520 PMCID： PMC3070760 DOI： 10.1097/WNR.0b013e3283416f81

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

22 in total

1. Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats.

Authors: Marcelo Febo; Annabell C Segarra; Jeffrey R Tenney; Mathew E Brevard; Timothy Q Duong; Craig F Ferris
Journal: J Neurosci Methods Date: 2004-10-30 Impact factor: 2.390

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Authors: G J Mogenson; C R Yang
Journal: Adv Exp Med Biol Date: 1991 Impact factor: 2.622

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Authors: B J Meyerson
Journal: Ann Med Exp Biol Fenn Date: 1968

4. Prefrontal cell firing in male rats during approach towards sexually receptive female: interactions with cocaine.

Authors: Marcelo Febo
Journal: Synapse Date: 2011-04 Impact factor: 2.562

5. Influence of estrous cycle and estradiol on behavioral sensitization to cocaine in female rats.

Authors: Stacy L Sell; Mary L Thomas; Kathryn A Cunningham
Journal: Drug Alcohol Depend Date: 2002-08-01 Impact factor: 4.492

6. Somatosensory determinants of lordosis in female rats: behavioral definition of the estrogen effect.

Authors: D Pfaff; M Montgomery; C Lewis
Journal: J Comp Physiol Psychol Date: 1977-02

7. Sexual-incentive motivation and paced sexual behavior in female rats after treatment with drugs modifying dopaminergic neurotransmission.

Authors: Ellinor Ellingsen; Anders Agmo
Journal: Pharmacol Biochem Behav Date: 2004-03 Impact factor: 3.533

BOLD signal response to cocaine varies with sexual receptivity in female rats.

1. Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats.

Review 2. The contribution of basal forebrain to limbic-motor integration and the mediation of motivation to action.

3. Amphetamine and 5-hydroxytryptamine inhibition of copulatory behaviour in the female rat.

4. Prefrontal cell firing in male rats during approach towards sexually receptive female: interactions with cocaine.

5. Influence of estrous cycle and estradiol on behavioral sensitization to cocaine in female rats.

6. Somatosensory determinants of lordosis in female rats: behavioral definition of the estrogen effect.

7. Sexual-incentive motivation and paced sexual behavior in female rats after treatment with drugs modifying dopaminergic neurotransmission.

8. Estrogen-sensitive neurons in the female rat ventral tegmental area: a dual route for the hormone action.

9. Biological basis of sex differences in the propensity to self-administer cocaine.

10. Amphetamine modulation of paced mating behavior.

Review 1. Early reproductive experiences in females make differences in cognitive function later in life.

Review 2. Applications in Awake Animal Magnetic Resonance Imaging.

3. Brain circuits activated by female sexual behavior evaluated by manganese enhanced magnetic resonance imaging.

Review 4. The power of using functional fMRI on small rodents to study brain pharmacology and disease.