| Literature DB >> 1158975 |
L W Tice, S H Wollman, R C Carter.
Abstract
The morphology of the tight junction of rat thyroid epithelium was examined in freeze-fractured material fixed in glutaraldehyde and briefly glycerinated. In normal thyroids the overall appearance of this junctional specialization resembled that of other cell types in many respects. Short-term changes in thyroid activity and hypophysectomy for 3 wk did not obviously affect the appearance of tight junctions. Feeding of the goitrogen, thiouracil, which stimulates secretion of thyroid-stimulating hormone, resulted in the appearance of some very narrow and some very wide, tight junctions or sometimes junctions with both wide and narrow regions within the same cell.Entities:
Mesh:
Substances:
Year: 1975 PMID: 1158975 PMCID: PMC2109449 DOI: 10.1083/jcb.66.3.657
Source DB: PubMed Journal: J Cell Biol ISSN: 0021-9525 Impact factor: 10.539