| Literature DB >> 11588264 |
L A Pennacchio1, M Olivier, J A Hubacek, J C Cohen, D R Cox, J C Fruchart, R M Krauss, E M Rubin.
Abstract
Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.Entities:
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Year: 2001 PMID： 11588264 DOI： 10.1126/science.1064852
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728