| Literature DB >> 11581415 |
C M Payne1, C J Heggie, D G Brownstein, J P Stewart, J P Quinn.
Abstract
Tachykinins function not only as neurotransmitters but also as immunological mediators. We used infection of tachykinin-deficient (PPT-A(-/-)) mice and wild-type controls with murine gammaherpesvirus to assess the role of tachykinins in the host response to a virus infection. Although infection was ultimately controlled in PPT-A(-/-) mice, there were higher titers of infectious virus in the lungs, accompanied by a more rapid influx of inflammatory cells. Clearance of latently infected cells from the spleen was also delayed. This is the first report of the direct influence of tachykinins in the host response to a virus infection.Entities:
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Year: 2001 PMID： 11581415 PMCID： PMC114621 DOI： 10.1128/JVI.75.21.10467-10471.2001
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103