Literature DB >> 11575950

Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species.

M J Uddin1, S Kokubo, K Ueda, K Suenaga, D Uemura.   

Abstract

Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

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Year:  2001        PMID： 11575950     DOI： 10.1021/np010066n

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  15 in total

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