Literature DB >> 11566018

Application of PNA and LNA oligomers to chemotherapy.

A N Elayadi1, D R Corey.   

Abstract

Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.

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Year:  2001        PMID： 11566018

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  6 in total

1.  LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.

Authors:  Fabien Darfeuille; Jens Bo Hansen; Henrik Orum; Carmelo Di Primo; Jean-Jacques Toulmé
Journal:  Nucleic Acids Res       Date:  2004-06-04       Impact factor: 16.971

Review 2.  pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents.

Authors:  Oleg A Andreev; Donald M Engelman; Yana K Reshetnyak
Journal:  Mol Membr Biol       Date:  2010-10-13       Impact factor: 2.857

3.  Design of antisense oligonucleotides stabilized by locked nucleic acids.

Authors:  Jens Kurreck; Eliza Wyszko; Clemens Gillen; Volker A Erdmann
Journal:  Nucleic Acids Res       Date:  2002-05-01       Impact factor: 16.971

4.  In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.

Authors:  Kees Fluiter; Anneloor L M A ten Asbroek; Marit B de Wissel; Marja E Jakobs; Margit Wissenbach; Håkan Olsson; Otto Olsen; Henrik Oerum; Frank Baas
Journal:  Nucleic Acids Res       Date:  2003-02-01       Impact factor: 16.971

5.  Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

Authors:  Arnold Grünweller; Eliza Wyszko; Birgit Bieber; Ricarda Jahnel; Volker A Erdmann; Jens Kurreck
Journal:  Nucleic Acids Res       Date:  2003-06-15       Impact factor: 16.971

6.  New approaches for cancer treatment: antitumor drugs based on gene-targeted nucleic acids.

Authors:  O A Patutina; N L Mironova; V V Vlassov; M A Zenkova
Journal:  Acta Naturae       Date:  2009-07       Impact factor: 1.845
  6 in total

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