Literature DB >> 11565103

Improved low-energy electron injection systems for high rate electron capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry.

Y O Tsybin1, P Håkansson, B A Budnik, K F Haselmann, F Kjeldsen, M Gorshkov, R A Zubarev.   

Abstract

New low-energy electron injection systems based on indirectly heated dispenser cathodes facilitate electron capture dissociation (ECD) in Fourier transform ion cyclotron resonance (FTICR) mass spectrometry. In this joint report, details are presented of the design and performance of these systems on two commercial FTICR instruments, 9.4 T Bruker BioAPEX in Uppsala and 4.7 T IonSpec Ultima in Odense. New results include obtaining meaningful one-scan MS/MS data for isolated precursor ions with millisecond irradiation times. The ECD rate improvement is not only due to the larger total electron current, but the larger emitting area as well. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2001        PMID： 11565103     DOI： 10.1002/rcm.448

Source DB:  PubMed          Journal:  Rapid Commun Mass Spectrom        ISSN： 0951-4198            Impact factor:   2.419


  31 in total

1.  Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue.

Authors:  Siu Kwan Sze; Ying Ge; HanBin Oh; Fred W McLafferty
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

2.  Optimization of experimental parameters for electron capture dissociation of peptides in a Fourier transform mass spectrometer.

Authors:  T W Dominic Chan; W H Herman Ip
Journal:  J Am Soc Mass Spectrom       Date:  2002-12       Impact factor: 3.109

3.  Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry.

Authors:  John E P Syka; Joshua J Coon; Melanie J Schroeder; Jeffrey Shabanowitz; Donald F Hunt
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-21       Impact factor: 11.205

4.  Electron capture dissociation distinguishes a single D-amino acid in a protein and probes the tertiary structure.

Authors:  Christopher M Adams; Frank Kjeldsen; Roman A Zubarev; Bogdan A Budnik; Kim F Haselmann
Journal:  J Am Soc Mass Spectrom       Date:  2004-07       Impact factor: 3.109

5.  Effects of charge state and cationizing agent on the electron capture dissociation of a peptide.

Authors:  Anthony T Iavarone; Kolja Paech; Evan R Williams
Journal:  Anal Chem       Date:  2004-04-15       Impact factor: 6.986

6.  Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins.

Authors:  Judith A Jebanathirajah; Jason L Pittman; Bruce A Thomson; Bogdan A Budnik; Parminder Kaur; Michael Rape; Marc Kirschner; Catherine E Costello; Peter B O'Connor
Journal:  J Am Soc Mass Spectrom       Date:  2005-11-02       Impact factor: 3.109

7.  Charge location directs electron capture dissociation of peptide dications.

Authors:  Yury O Tsybin; Kim F Haselmann; Mark R Emmett; Christopher L Hendrickson; Alan G Marshall
Journal:  J Am Soc Mass Spectrom       Date:  2006-09-11       Impact factor: 3.109

8.  Characterization of an N-acylated glucagon-like peptide-1 derivative by electron capture dissociation.

Authors:  Kim F Haselmann; Per F Nielsen; Roman A Zubarev
Journal:  J Am Soc Mass Spectrom       Date:  2005-04       Impact factor: 3.109

9.  Protein identification via surface-induced dissociation in an FT-ICR mass spectrometer and a patchwork sequencing approach.

Authors:  Facundo M Fernandez; Vicki H Wysocki; Jean H Futrell; Julia Laskin
Journal:  J Am Soc Mass Spectrom       Date:  2006-03-15       Impact factor: 3.109

10.  Electron capture dissociation implementation progress in Fourier transform ion cyclotron resonance mass spectrometry.

Authors:  Yury O Tsybin; John P Quinn; Oleg Yu Tsybin; Christopher L Hendrickson; Alan G Marshall
Journal:  J Am Soc Mass Spectrom       Date:  2008-03-04       Impact factor: 3.109
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