| Literature DB >> 1156406 |
G M Powell, J G Jones, A H Olavesen, C G Curtis.
Abstract
1. The biliary excretion of phenolphthalein di[35S]sulphate was studied in rats. 2. The conjugate was administered by continuous infusion at rates of 3, 4.5, 6, 9 and 12 mug/min, and kinetic analysis of the rate of biliary excretion was consistent with a two-compartment open-model system. 3. The results obtained after single injections of the ester were also consistent with the model. 4. An essential feature of the model is the presence of a compartment into which the ester may pass as an alternative to direct excretion via the bile. 5. It is suggested that such a compartment may be located within the liver.Entities:
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Year: 1975 PMID： 1156406 PMCID： PMC1165538 DOI： 10.1042/bj1480303
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857