Literature DB >> 11563108

Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs.

D Egron1, C Périgaud, G Gosselin, A M Aubertin, J L Imbach.   

Abstract

The synthesis and the study of new mononucleoside phosphoramidate diesters bearing S-acyl-2-thioethyl (SATE) groups and an alkylamino residue are reported. The studied compounds appear to be able to deliver the corresponding 5'-mononucleotide inside the cells, and could be considered as prototypes for a new kind of mononucleotide prodrugs (pronucleotides).

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Year:  2001        PMID: 11563108     DOI: 10.1081/NCN-100002422

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  2 in total

Review 1.  Synthesis of nucleoside phosphate and phosphonate prodrugs.

Authors:  Ugo Pradere; Ethel C Garnier-Amblard; Steven J Coats; Franck Amblard; Raymond F Schinazi
Journal:  Chem Rev       Date:  2014-08-21       Impact factor: 60.622

2.  Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene.

Authors:  Carlos María Galmarini; Marilyn L Clarke; Lars Jordheim; Cheryl L Santos; Emeline Cros; John R Mackey; Charles Dumontet
Journal:  BMC Pharmacol       Date:  2004-05-24
  2 in total

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