| Literature DB >> 11563079 |
H Chapman1, M Kernan, E Prisbe, J Rohloff, M Sparacino, T Terhorst, R Yu.
Abstract
The practical synthesis of a mixed phenoxy-amidate derivative of PMPA with high oral bioavailability and favorable pharmacokinetics is described. The non-stereoselective synthetic route produces a 1:1 mixture of two diastereomers at phosphorous. Simulated moving bed chromatography using Chiralpak AS enabled kilo-scale isolation of the more potent diastereomer (GS-7340). The GS-7340 phosphorous chiral center was found to be (S) by X-ray crystallography.Entities:
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Year: 2001 PMID： 11563079 DOI： 10.1081/NCN-100002338
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381