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Literature DB >> 1155924

Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against.

Abstract

The effectiveness of three semisynthetic, penicillinase-resistant penicillins alone and in combination with gentamicin was tested against 29 clinical isolates of enterococci. The minimal inhibitory concentrations of nafcillin were considerably lower than those of oxacillin and methicillin but were slightly higher than those of penicillin. At clinically achievable concentrations, the combination of nafcillin plus gentamicin produced enhanced killing against 13 of 14 strains of enterococci and was synergistic (by very rigid criteria) against 10 of 14 strains. In contrast, combinations of oxacillin plus gentamicin were synergistic against only 3 of 14 strains, and methicillin plus gentamicin produced synergistic killing against only 1 of 14 strains.

Entities: Chemical

Mesh：

Substances：

Year: 1975 PMID： 1155924 PMCID： PMC429234 DOI： 10.1128/AAC.7.6.828

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

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Authors: L A RANTZ; E RANDALL
Journal: Stanford Med Bull Date: 1955-05

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Authors: E JAWETZ; J B GUNNISON
Journal: Pharmacol Rev Date: 1953-06 Impact factor: 25.468

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Authors: E Jawetz; J B Gunnison; V R Coleman
Journal: Science Date: 1950-03-10 Impact factor: 47.728

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Authors: W C ROBBINS; R TOMPSETT
Journal: Am J Med Date: 1951-03 Impact factor: 4.965

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Authors: A J Weinstein; R C Moellering
Journal: JAMA Date: 1973-02-26 Impact factor: 56.272

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Authors: G L Mandell; D Kaye; M E Levison; E W Hook
Journal: Arch Intern Med Date: 1970-02

Review 7. Treatment of infective endocarditis--1973.

Authors: L Weinstein; J Schlesinger
Journal: Prog Cardiovasc Dis Date: 1973 Nov-Dec Impact factor: 8.194

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Authors: E Jawetz; M Sonne
Journal: N Engl J Med Date: 1966-03-31 Impact factor: 91.245

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Authors: R R Facklam
Journal: Appl Microbiol Date: 1973-08

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Authors: G H McCracken; J D Nelson; M L Thomas
Journal: Antimicrob Agents Chemother Date: 1973-03 Impact factor: 5.191

11 in total

1. Synergism of oxacillin and gentamicin against enterococci.

Authors: R L Marier; N Joyce; V T Andriole
Journal: Antimicrob Agents Chemother Date: 1975-11 Impact factor: 5.191

2. In vitro activity of SK&F 104662, a new glycopeptide antibiotic.

Authors: J D Yao; G M Eliopoulos; R C Moellering
Journal: Antimicrob Agents Chemother Date: 1989-06 Impact factor: 5.191

3. Synergism of cefazolin-gentamicin against enterococci.

Authors: M Bourque; R Quintiliani; R C Tilton
Journal: Antimicrob Agents Chemother Date: 1976-07 Impact factor: 5.191

4. Synergy of combinations of vancomycin, gentamicin, and rifampin against methicillin-resistant, coagulase-negative staphylococci.

Authors: F D Lowy; D S Chang; P R Lash
Journal: Antimicrob Agents Chemother Date: 1983-06 Impact factor: 5.191

5. Penicillinase-resistant penicillins plus gentamicin in experimental enterococcal endocarditis.

Authors: L J Lincoln; A J Weinstein; M Gallagher; E Abrutyn
Journal: Antimicrob Agents Chemother Date: 1977-10 Impact factor: 5.191

6. Synergy in the antimicrobial action of penicillin and beta-chloro-D-alanine in vitro.

Authors: T S Soper; J M Manning
Journal: Antimicrob Agents Chemother Date: 1976-02 Impact factor: 5.191

7. Efficacy of teicoplanin in two dosage regimens for experimental endocarditis caused by a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin.

Authors: J D Yao; C Thauvin-Eliopoulos; G M Eliopoulos; R C Moellering
Journal: Antimicrob Agents Chemother Date: 1990-05 Impact factor: 5.191

8. Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci.

Authors: C Watanakunakorn; C Glotzbecker
Journal: Antimicrob Agents Chemother Date: 1977-01 Impact factor: 5.191

9. Effect of protein binding on the activity of penicillins in combination with gentamicin against enterococci.

Authors: R H Glew; R C Moellering
Journal: Antimicrob Agents Chemother Date: 1979-01 Impact factor: 5.191

10. Unusually high occurrence of drug reactions with nafcillin.

Authors: B Zakhireh; R K Root
Journal: Yale J Biol Med Date: 1978 Jul-Aug