Literature DB >> 1155304

The optimization test in the guinea-pig. A method for the predictive evaluation of the contact allergenicity of chemicals.

T Maurer, P Thomann, E G Weirich, R Hess.   

Abstract

Guinea-pigs were sensitized with various substances (DNCB, penicillin G, PPL, ethylaminobenzoate, formalin) by the Draize method, the maximization method and the new optimization method (intracutaneous test employing adjuvant). The advantages of the optimization method favouring its adoption as a standard sensitization test are discussed in the light of the results obtained by this method and with the two established tests.

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Year:  1975        PMID： 1155304     DOI： 10.1007/bf02027360

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  DELAYED CONTACT HYPERSENSITIVITY IN THE GUINEA PIG.

Authors:  E V BUEHLER
Journal:  Arch Dermatol       Date:  1965-02

2.  [Examination technics for the diagnosis of delayed hypersensitivity as demonstrated on the example of experimental allergic contact eczema].

Authors:  H Sochor
Journal:  Dermatol Monatsschr       Date:  1973-01

3.  The most common contact allergens 1968-1970.

Authors:  R L Baer; D L Ramsey; E Biondi
Journal:  Arch Dermatol       Date:  1973-07

4.  Epidemiology of contact dermatitis in North America: 1972.

Authors: 
Journal:  Arch Dermatol       Date:  1973-10

5.  [Experience with the lymphocyte transformation test (LTT) in the diagnosis of humoral and cellular-type allergies].

Authors:  E Schöpf
Journal:  Z Haut Geschlechtskr       Date:  1971-01-15

6.  The identification of contact allergens by animal assay. The guinea pig maximization test.

Authors:  B Magnusson; A M Kligman
Journal:  J Invest Dermatol       Date:  1969-03       Impact factor: 8.551

7.  Studies of the macrophage inhibition test. I. Comparison of the skin and cell migration reactions during the course of development of delayed hypersensitivity.

Authors:  R W Ferraresi; C T Dedrick; S Raffel; M Goihman-Yahr
Journal:  J Immunol       Date:  1969-04       Impact factor: 5.422

8.  The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers.

Authors:  A M Kligman
Journal:  J Invest Dermatol       Date:  1966-11       Impact factor: 8.551
  8 in total
  3 in total

Review 1.  A differentiated approach to testing skin sensitization. Proposal for a new test guideline skin sensitization.

Authors:  E Schlede; T Maurer; M Potokar; W M Schmidt; K H Schulz; R Roll; D Kayser
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

2.  A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study.

Authors:  I Kimber; C Weisenberger
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

3.  [Effect of dermatocorticoids on the activity of hepatic tryptophane pyrrolase in the guinea pig (author's transl)].

Authors:  W Albrecht; J K Longauer; E G Weirich
Journal:  Arch Dermatol Res       Date:  1979-07-30       Impact factor: 3.017
  3 in total

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