Literature DB >> 11544225

Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa.

K Madduri1, C Waldron, D J Merlo.   

Abstract

Rhamnose is an essential component of the insect control agent spinosad. However, the genes coding for the four enzymes involved in rhamnose biosynthesis in Saccharopolyspora spinosa are located in three different regions of the genome, all unlinked to the cluster of other genes that are required for spinosyn biosynthesis. Disruption of any of the rhamnose genes resulted in mutants with highly fragmented mycelia that could survive only in media supplemented with an osmotic stabilizer. It appears that this single set of genes provides rhamnose for cell wall synthesis as well as for secondary metabolite production. Duplicating the first two genes of the pathway caused a significant improvement in the yield of spinosyn fermentation products.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11544225      PMCID： PMC95454          DOI： 10.1128/JB.183.19.5632-5638.2001

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  10 in total

Review 1.  Genes and enzymes involved in deoxysugar biosynthesis in bacteria.

Authors:  A Trefzer; J A Salas; A Bechthold
Journal:  Nat Prod Rep       Date:  1999-06       Impact factor: 13.423

2.  Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.

Authors:  C Waldron; P Matsushima; P R Rosteck; M C Broughton; J Turner; K Madduri; K P Crawford; D J Merlo; R H Baltz
Journal:  Chem Biol       Date:  2001-05

3.  The dnrM gene in Streptomyces peucetius contains a naturally occurring frameshift mutation that is suppressed by another locus outside of the daunorubicin-production gene cluster.

Authors:  Mark A Gallo; Joanne Ward; C R Hutchinson
Journal:  Microbiology (Reading)       Date:  1996-02       Impact factor: 2.777

4.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

Authors:  J D Thompson; D G Higgins; T J Gibson
Journal:  Nucleic Acids Res       Date:  1994-11-11       Impact factor: 16.971

5.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

6.  Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.

Authors:  Richard G Summers; Stefano Donadio; Michael J Staver; Evelyn Wendt-Pienkowski; C Richard Hutchinson; Leonard Katz
Journal:  Microbiology (Reading)       Date:  1997-10       Impact factor: 2.777

7.  Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Authors:  M Bierman; R Logan; K O'Brien; E T Seno; R N Rao; B E Schoner
Journal:  Gene       Date:  1992-07-01       Impact factor: 3.688

Review 8.  Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

Authors:  H W Liu; J S Thorson
Journal:  Annu Rev Microbiol       Date:  1994       Impact factor: 15.500

9.  Conjugal transfer of cosmid DNA from Escherichia coli to Saccharopolyspora spinosa: effects of chromosomal insertions on macrolide A83543 production.

Authors:  P Matsushima; M C Broughton; J R Turner; R H Baltz
Journal:  Gene       Date:  1994-08-19       Impact factor: 3.688

10.  Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea.

Authors:  K J Linton; B W Jarvis; C R Hutchinson
Journal:  Gene       Date:  1995-02-03       Impact factor: 3.688
  10 in total
  28 in total

Review 1.  Natural product derived insecticides: discovery and development of spinetoram.

Authors:  Ute Galm; Thomas C Sparks
Journal:  J Ind Microbiol Biotechnol       Date:  2015-11-18       Impact factor: 3.346

2.  Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis.

Authors:  Andrij Fedashchin; William H Cernota; Melissa C Gonzalez; Benjamin I Leach; Noelle Kwan; Roy K Wesley; J Mark Weber
Journal:  FEMS Microbiol Lett       Date:  2015-10-13       Impact factor: 2.742

3.  Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.

Authors:  Sonia Gullón; Carlos Olano; Mohamed S Abdelfattah; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

4.  In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.

Authors:  Lin Hong; Zongbao Zhao; Charles E Melançon; Hua Zhang; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2008-03-18       Impact factor: 15.419

5.  Bioactive compounds from marine actinomycetes.

Authors:  Renu Solanki; Monisha Khanna; Rup Lal
Journal:  Indian J Microbiol       Date:  2009-01-08       Impact factor: 2.461

6.  High Level of Spinosad Production in the Heterologous Host Saccharopolyspora erythraea.

Authors:  Jun Huang; Zhen Yu; Mei-Hong Li; Ji-Dong Wang; Hua Bai; Jun Zhou; Yu-Guo Zheng
Journal:  Appl Environ Microbiol       Date:  2016-08-30       Impact factor: 4.792

7.  A streamlined metabolic pathway for the biosynthesis of moenomycin A.

Authors:  Bohdan Ostash; Alan Saghatelian; Suzanne Walker
Journal:  Chem Biol       Date:  2007-03

Review 8.  Natural-product sugar biosynthesis and enzymatic glycodiversification.

Authors:  Christopher J Thibodeaux; Charles E Melançon; Hung-wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

9.  Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.

Authors:  Leonard Kaysser; Liane Lutsch; Stefanie Siebenberg; Emmanuel Wemakor; Bernd Kammerer; Bertolt Gust
Journal:  J Biol Chem       Date:  2009-04-07       Impact factor: 5.157

10.  SpnH from Saccharopolyspora spinosa encodes a rhamnosyl 4'-O-methyltransferase for biosynthesis of the insecticidal macrolide, spinosyn A.

Authors:  Ke-xue Huang; James Zahn; Lei Han
Journal:  J Ind Microbiol Biotechnol       Date:  2008-08-14       Impact factor: 3.346
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.