Literature DB >> 11544022

Integrin tyrosine phosphorylation in platelet signaling.

D R Phillips1, K S Prasad, J Manganello, M Bao, L Nannizzi-Alaimo.   

Abstract

The beta 3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta 3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta-integrin cytoplasmic domain. Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals.

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Year:  2001        PMID： 11544022     DOI： 10.1016/s0955-0674(00)00250-7

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  34 in total

1.  Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens.

Authors:  Gavin E Jarvis; Ben T Atkinson; Daniel C Snell; Steve P Watson
Journal:  Br J Pharmacol       Date:  2002-09       Impact factor: 8.739

2.  Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

Authors:  Koji Eto; Ronan Murphy; Steve W Kerrigan; Alessandra Bertoni; Heidi Stuhlmann; Toru Nakano; Andrew D Leavitt; Sanford J Shattil
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-18       Impact factor: 11.205

3.  Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.

Authors:  Olga Vinogradova; Julia Vaynberg; Xiangming Kong; Thomas A Haas; Edward F Plow; Jun Qin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

4.  Tyrosine phosphorylation as a conformational switch: a case study of integrin β3 cytoplasmic tail.

Authors:  Lalit Deshmukh; Nahum Meller; Nathan Alder; Tatiana Byzova; Olga Vinogradova
Journal:  J Biol Chem       Date:  2011-09-28       Impact factor: 5.157

5.  Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii.

Authors:  Ciara Keane; Helen Petersen; Kieran Reynolds; Debra K Newman; Dermot Cox; Howard F Jenkinson; Peter J Newman; Steven W Kerrigan
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-11-11       Impact factor: 8.311

6.  p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration.

Authors:  Zhilun Li; Hongquan Zhang; Lars Lundin; Minna Thullberg; Yajuan Liu; Yunling Wang; Lena Claesson-Welsh; Staffan Strömblad
Journal:  J Biol Chem       Date:  2010-05-27       Impact factor: 5.157

Review 7.  Structure and function of the platelet integrin alphaIIbbeta3.

Authors:  Joel S Bennett
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

Review 8.  Minding the gaps to promote thrombus growth and stability.

Authors:  Lawrence F Brass; Li Zhu; Timothy J Stalker
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

Review 9.  Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress.

Authors:  David R Clemmons; Laura A Maile; Yan Ling; J Yarber; Walker H Busby
Journal:  Growth Horm IGF Res       Date:  2007-04-06       Impact factor: 2.372

10.  Structural insights into the recognition of β3 integrin cytoplasmic tail by the SH3 domain of Src kinase.

Authors:  Priya Katyal; Robbins Puthenveetil; Olga Vinogradova
Journal:  Protein Sci       Date:  2013-09-04       Impact factor: 6.725
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