Literature DB >> 16322781

Structure and function of the platelet integrin alphaIIbbeta3.

Joel S Bennett1.   

Abstract

The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.

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Year:  2005        PMID： 16322781      PMCID： PMC1297263          DOI： 10.1172/JCI26989

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  99 in total

1.  A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.

Authors:  O Vinogradova; T Haas; E F Plow; J Qin
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

2.  Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.

Authors:  Renhao Li; Neal Mitra; Holly Gratkowski; Gaston Vilaire; Rustem Litvinov; Chandrasekaran Nagasami; John W Weisel; James D Lear; William F DeGrado; Joel S Bennett
Journal:  Science       Date:  2003-05-02       Impact factor: 47.728

3.  Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.

Authors:  Olga Vinogradova; Julia Vaynberg; Xiangming Kong; Thomas A Haas; Edward F Plow; Jun Qin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

4.  The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

Authors:  S E D'Souza; M H Ginsberg; T A Burke; E F Plow
Journal:  J Biol Chem       Date:  1990-02-25       Impact factor: 5.157

5.  A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding.

Authors:  E C Tozer; E K Baker; M H Ginsberg; J C Loftus
Journal:  Blood       Date:  1999-02-01       Impact factor: 22.113

6.  Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).

Authors:  T Kamata; A Irie; M Tokuhira; Y Takada
Journal:  J Biol Chem       Date:  1996-08-02       Impact factor: 5.157

7.  Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

Authors:  A Senes; M Gerstein; D M Engelman
Journal:  J Mol Biol       Date:  2000-02-25       Impact factor: 5.469

8.  Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits.

Authors:  A Armulik; I Nilsson; G von Heijne; S Johansson
Journal:  J Biol Chem       Date:  1999-12-24       Impact factor: 5.157

9.  The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

Authors:  T K Gartner; J S Bennett
Journal:  J Biol Chem       Date:  1985-10-05       Impact factor: 5.157

10.  Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes.

Authors:  A Duperray; R Berthier; E Chagnon; J J Ryckewaert; M Ginsberg; E Plow; G Marguerie
Journal:  J Cell Biol       Date:  1987-06       Impact factor: 10.539
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  111 in total

Review 1.  Regulation of platelet beta 3 integrins.

Authors:  Joel S Bennett; David T Moore
Journal:  Haematologica       Date:  2010-07       Impact factor: 9.941

2.  Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force.

Authors:  Rustem I Litvinov; Valeri Barsegov; Andrew J Schissler; Andrew R Fisher; Joel S Bennett; John W Weisel; Henry Shuman
Journal:  Biophys J       Date:  2011-01-05       Impact factor: 4.033

3.  Immunodiagnosis of platelet activation in immune thrombocytopenia through scFv antibodies cognate to activated IIb3 integrins.

Authors:  Preeti Bhoria; Neelam Varma; Pankaj Malhotra; Subhash Varma; Manni Luthra-Guptasarma
Journal:  MAbs       Date:  2015-08-24       Impact factor: 5.857

4.  Did dinosaurs have megakaryocytes? New ideas about platelets and their progenitors.

Authors:  Lawrence F Brass
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

Review 5.  Minding the gaps to promote thrombus growth and stability.

Authors:  Lawrence F Brass; Li Zhu; Timothy J Stalker
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

6.  The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.

Authors:  Tong-Lay Lau; Chungho Kim; Mark H Ginsberg; Tobias S Ulmer
Journal:  EMBO J       Date:  2009-03-12       Impact factor: 11.598

7.  Resolving two-dimensional kinetics of the integrin αIIbβ3-fibrinogen interactions using binding-unbinding correlation spectroscopy.

Authors:  Rustem I Litvinov; Andrey Mekler; Henry Shuman; Joel S Bennett; Valeri Barsegov; John W Weisel
Journal:  J Biol Chem       Date:  2012-08-14       Impact factor: 5.157

8.  Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration.

Authors:  Dake Hao; Wenwu Xiao; Ruiwu Liu; Priyadarsini Kumar; Yuanpei Li; Ping Zhou; Fuzheng Guo; Diana L Farmer; Kit S Lam; Fengshan Wang; Aijun Wang
Journal:  ACS Chem Biol       Date:  2017-03-02       Impact factor: 5.100

Review 9.  Integrin αIIbβ3: from discovery to efficacious therapeutic target.

Authors:  Kamila Bledzka; Susan S Smyth; Edward F Plow
Journal:  Circ Res       Date:  2013-04-12       Impact factor: 17.367

10.  Genetic variability in platelet integrin α2β1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia.

Authors:  Fernanda M F Campos; Marina L S Santos; Flora S Kano; Cor J F Fontes; Marcus V G Lacerda; Cristiana F A Brito; Luzia H Carvalho
Journal:  Am J Trop Med Hyg       Date:  2012-12-18       Impact factor: 2.345
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