Literature DB >> 11543675

N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets.

S Hanessian1, N Moitessier, C Gauchet, M Viau.   

Abstract

A series of N-arylsulfonyl S-alkyl homocysteine hydroxamic acids were synthesized with variations in three subsites corresponding to P(1), P(1)', and P(2)'. Enzyme assays with a variety of MMPs revealed activity at the low nanomolar level.

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Year:  2001        PMID： 11543675     DOI： 10.1021/jm010097f

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  One-pot multicomponent synthesis of two novel thiolactone scaffolds.

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2.  Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.

Authors:  Lionel Kuntz; Denis Tritsch; Catherine Grosdemange-Billiard; Andréa Hemmerlin; Audrey Willem; Thomas J Bach; Michel Rohmer
Journal:  Biochem J       Date:  2005-02-15       Impact factor: 3.857

3.  Chlorhexidine stabilizes the adhesive interface: a 2-year in vitro study.

Authors:  Lorenzo Breschi; Annalisa Mazzoni; Fernando Nato; Marcela Carrilho; Erika Visintini; Leo Tjäderhane; Alessandra Ruggeri; Franklin R Tay; Elettra De Stefano Dorigo; David H Pashley
Journal:  Dent Mater       Date:  2009-12-31       Impact factor: 5.304

4.  Reactions of N-benzyloxycarbamate derivatives with stabilized carbon nucleophiles: a new synthetic approach to polyhydroxamic acids and other hydroxamate-containing mixed ligand systems.

Authors:  Yuan Liu; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  J Org Chem       Date:  2009-01-16       Impact factor: 4.354

5.  Important role of matrix metalloproteinase 9 in epileptogenesis.

Authors:  Grzegorz M Wilczynski; Filip A Konopacki; Ewa Wilczek; Zofia Lasiecka; Adam Gorlewicz; Piotr Michaluk; Marcin Wawrzyniak; Monika Malinowska; Pawel Okulski; Lukasz R Kolodziej; Witold Konopka; Kamila Duniec; Barbara Mioduszewska; Evgeni Nikolaev; Agnieszka Walczak; Dorota Owczarek; Dariusz C Gorecki; Werner Zuschratter; Ole Petter Ottersen; Leszek Kaczmarek
Journal:  J Cell Biol       Date:  2008-03-10       Impact factor: 10.539
  5 in total

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