| Literature DB >> 11542282 |
I A Kozlov1, B De Bouvere, A Van Aerschot, P Herdewijn, L E Orgel.
Abstract
Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonensymatic template-directed reactions. HNA heterosequences appeared to be superior to the corresponding DNA heterosequences in facilitating synthesis of complementary oligonucleotides from nucleoside-5'-phosphoro-2-methyl imidazolides.Entities:
Keywords: NASA Discipline Exobiology; Non-NASA Center
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Year: 1999 PMID： 11542282 DOI： 10.1021/ja990440u
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419