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Literature DB >> 11542188

Some acyclic analogues of nucleotides and their template-directed reactions.

Abstract

Bismonophosphoimidazolides of acyclic analogues of guanosine IV and adenosine V were synthesized. They undergo oligomerization in the presence of complementary polynucleotide templates. Details of their synthesis and their subsequent template- and nontemplate-directed reactions are described, and their possible relevance to the origin of life is discussed.

Entities: Chemical

Keywords: NASA Discipline Exobiology; Non-NASA Center

Mesh：

Substances：

Year: 1989 PMID： 11542188 DOI： 10.1007/bf02603071

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

10 in total

1. A simple one-step synthesis of ribonucleoside 2',3'-cyclic phosphate 5'-phosphates.

Authors: A Simoncsits; J Tomasz
Journal: Biochim Biophys Acta Date: 1975-06-02

2. Template-directed synthesis of novel, nucleic acid-like structures.

Authors: A W Schwartz; L E Orgel
Journal: Science Date: 1985-05-03 Impact factor: 47.728

3. The case for an ancestral genetic system involving simple analogues of the nucleotides.

Authors: G F Joyce; A W Schwartz; S L Miller; L E Orgel
Journal: Proc Natl Acad Sci U S A Date: 1987-07 Impact factor: 11.205

4. Template-directed synthesis of acyclic oligonucleotide analogues.

Authors: J Visscher; A W Schwartz
Journal: J Mol Evol Date: 1988 Dec-1989 Feb Impact factor: 2.395

5. Origin of life: consideration of alternatives to proteins and nucleic acids.

Authors: G L Nelsestuen
Journal: J Mol Evol Date: 1980-03 Impact factor: 2.395

6. Synthesis and anti-herpes-virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine.

Authors: J C Martin; D P McGee; G A Jeffrey; D W Hobbs; D F Smee; T R Matthews; J P Verheyden
Journal: J Med Chem Date: 1986-08 Impact factor: 7.446

7. Nucleic acid-like structures. II. Polynucleotide analogues as possible primitive precursors of nucleic acids.

Authors: A W Schwartz; J Visscher; C G Bakker; J Niessen
Journal: Orig Life Evol Biosph Date: 1987 Impact factor: 1.950

8. Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.

Authors: S Phadtare; J Zemlicka
Journal: J Med Chem Date: 1987-02 Impact factor: 7.446

9. 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent.

Authors: J C Martin; C A Dvorak; D F Smee; T R Matthews; J P Verheyden
Journal: J Med Chem Date: 1983-05 Impact factor: 7.446

10. Prebiotic synthesis of methionine.

Authors: J E Van Trump; S L Miller
Journal: Science Date: 1972-11-24 Impact factor: 47.728

10 in total

6 in total

Some acyclic analogues of nucleotides and their template-directed reactions.

1. A simple one-step synthesis of ribonucleoside 2',3'-cyclic phosphate 5'-phosphates.

2. Template-directed synthesis of novel, nucleic acid-like structures.

3. The case for an ancestral genetic system involving simple analogues of the nucleotides.

4. Template-directed synthesis of acyclic oligonucleotide analogues.

5. Origin of life: consideration of alternatives to proteins and nucleic acids.

6. Synthesis and anti-herpes-virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine.

7. Nucleic acid-like structures. II. Polynucleotide analogues as possible primitive precursors of nucleic acids.

8. Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.

9. 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent.

10. Prebiotic synthesis of methionine.

1. Template-directed synthesis of oligonucleotides under eutectic conditions.

2. Computer simulation in template-directed oligonucleotide synthesis.

3. Polymerization of the cyclic pyrophosphates of nucleosides and their analogues.

4. Template-directed oligomerization of 5'-deoxy-5'-nucleosideacetic acid derivatives.

5. Pyrophosphate formation as the most efficient condensation reaction of activated nucleotides.

6. Some biochemical properties of an acyclic oligonucleotide analogue. A plausible ancestor of the DNA?