| Literature DB >> 11537959 |
S K Chapes1, D R Morrison, J A Guikema, M L Lewis, B S Spooner.
Abstract
B6MP102 cells, a continuously cultured murine bone marrow macrophage cell line, were tested for secretion of tumor necrosis factor-alpha and Interleukin-1 during space flight. We found that B6MP102 cells secreted more tumor necrosis factor-alpha and interleukin-1 when stimulated in space with lipopolysaccharide than controls similarly stimulated on earth. This compared to increased secretion of interferon-beta and -gamma by lymphocytes that was measured on the same shuttle flights. Although space flight enhanced B6MP102 secretion of tumor necrosis factor-alpha, an experiment on a subsequent space flight (STS-50) found that cellular cytotoxicity, mediated by tumor necrosis factor-alpha, was inhibited.Entities:
Keywords: NASA Center JSC; NASA Discipline Cell Biology; NASA Discipline Number 00-00; NASA Discipline Number 40-20; NASA Discipline Number 93-10; NASA Program Flight; NASA Program NSCORT; NASA Program Space Biology; Non-NASA Center
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Year: 1994 PMID： 11537959 DOI： 10.1016/0273-1177(94)90380-8
Source DB: PubMed Journal: Adv Space Res ISSN： 0273-1177 Impact factor: 2.152